AI Article Synopsis
- The study investigates the presence of human cytomegalovirus (HCMV) in various odontogenic cysts and tumors, specifically dentigerous cysts (DC), odontogenic keratocysts (OKC), and ameloblastomas (AB).
- HCMV-DNA and glycoprotein B (gB) detection revealed a higher prevalence in ameloblastoma samples, suggesting a potential link between the virus and tumor development.
- The study recommends using immunohistochemistry (IHC) for improved detection of HCMV in odontogenic tumors, particularly in ameloblastoma.
Article Abstract
The factor behind the activation of the remnant odontogenic tissues and development of odontogenic cysts and tumors is poorly understood.This study aimed to investigate the presence of human cytomegalovirus (HCMV) in dentigerous cyst (DC), odontogenic keratocyst (OKC), and ameloblastoma (AB). The study included 41 samples, which distributed into DC (n=13), OKC (n=12), and AB (n=16). Conventional PCR assay and IHC analysis were used to detect the HCMV-DNA and HCMV glycoprotein B (HCMV-gB) respectively. HCMV-DNA was detected in 10 samples (62.5%) of AB, four samples (30.8%) of DC, and three samples (25 %) of OKC respectively (χ test = 1.195, p= 0.247). Meanwhile, HCMV-gB was found in 12 (75%) of AB, in 2 (15.4%) of DC, and absent in OKC (0.0%) (χ test = 4.122, p= 0.042). The high prevalence of HCMV inside the odontogenic epithelium of AB could indicate a possible role of the virus in the oncogenesis and/or oncomodulation of the AB. Additionally, we recommend the IHC for the detection of HCMV in the odontogenic tumors like AB.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832985 | PMC |
| http://dx.doi.org/10.1080/20002297.2021.1874699 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!