The Universal Space-Time Mapping Hypothesis suggests that temporal expression is based on spatial metaphor for all human beings. This study examines its applicability in the Chinese language using the data elicited from the Early Childhood Mandarin Corpus (ECMC) (Li and Tse, 2011), which collected the utterances produced by 168 Mandarin-speaking preschoolers in a semistructured play context. The unique pair of Chinese words, (/before/front) and (/after/back), which can be used to express either time (before/after) or space (front/back) in daily communication, was the unit of analysis. The results indicated that: (1) there was a significant age effect in the production of "qian/hou," indicating that the period before the age of 4.5 may be critical for the development of temporal and spatial expression; (2) the pair was produced to express time (before/after) much earlier than space (front/back), indicating that the expression of time might not necessarily be based on the spatial metaphor; and (3) the pair was used more frequently to express time (before/after) than space (front/back) by the preschoolers, thus challenging the hypothesis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847851 | PMC |
http://dx.doi.org/10.3389/fpsyg.2020.565763 | DOI Listing |
Development
January 2025
Pediatric Genomics Discovery Program, Departments of Pediatrics and Genetics, Yale School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA.
Emerging evidence suggests that the nuclear pore complex can have unique compositions and distinct nucleoporin functions in different cells. Here, we show that Nup107, a key component of the NPC scaffold, varies in expression over development: it is expressed at higher levels in the blastula compared to the gastrula suggesting a critical role prior to gastrulation. We find depletion of Nup107 affects the differentiation of the early germ layers leading to an expansion of the ectoderm at the expense of endoderm and mesoderm.
View Article and Find Full Text PDFEndocr Metab Immune Disord Drug Targets
January 2025
Department of Radiotherapy, Suzhou Ninth People's Hospital, Suzhou, 215200, China.
Background: Liquid-Liquid Phase Separation (LLPS) is a process involved in the formation of established organelles and various condensates that lack membranes; however, the relationship between LLPS and Ulcerative Colitis (UC) remains unclear.
Aims: This study aimed to comprehensively clarify the correlation between ulcerative colitis (UC) and liquid-liquid phase separation (LLPS).
Objectives: In this study, bioinformatics analyses and public databases were applied to screen and validate key genes associated with LLPS in UC.
Recent Pat Anticancer Drug Discov
January 2025
Department of Hematology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, P.R. China.
Background: BCL-2 was the first gene identified to have antiapoptotic effects, and venetoclax is an oral selective BCL-2 inhibitor, which has great potential in the treatment of patients with acute myeloid leukemia (AML) who are not candidates for intensive therapy. Notably, posaconazole, an oral antifungal drug, is also a strong factor that can affect blood venetoclax concentrations. To the best of our knowledge, the relationship between BCL-2 expression, posaconazole, and venetoclax, as well as their influence on treatment efficacy and the prognosis of patients with AML, has not been reported.
View Article and Find Full Text PDFIndian J Psychiatry
November 2024
National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India.
Drug courts are specialized programs from the courts that aim to offer a chance to individuals with substance-related problems encountering law enforcement to take treatment rather than face incarceration. The aim of this debate is to critically debate the utility, applicability, and feasibility of drug courts in India. This is a theoretical debate based on the existing evidence and considerations of ground realities in the country.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
January 2025
Clinical Studies Group, Randox Laboratories Ltd, Crumlin, United Kingdom.
Background: In patients undergoing orthopaedic trauma surgery, acute kidney injury (AKI) can develop post-operatively and is a major cause of increased mortality and hospital stay time. Development of AKI is associated with three main processes: inflammation, ischaemia-reperfusion injury (IRI) and hypoperfusion. In this study, we investigated whether ratios of urine and blood anti-inflammatory biomarkers and biomarkers of hypoperfusion, IRI and inflammation are elevated in patients who develop post-trauma orthopaedic surgery acute kidney injury (PTOS-AKI).
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!