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A retrospective study on a small group of female workers accidentally intoxicated by organic solvents (toluene and aliphatic hydrocarbons) evaluated complaints of residual memory impairment. Memory testing was first performed two months after the intoxication with a follow-up six months later to assess recovery. The workers showed normal patterns of performance on tests of learning and short-term and longer-term memory, but marked difficulties were observed when attention had to be allocated between two resource-competing tasks. As there was no evidence of recovery by the follow-up session, the results indicate that solvent intoxication can cause neuropsychological sequelae lasting for over eight months.
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http://dx.doi.org/10.5271/sjweh.1951 | DOI Listing |
Toxicol Lett
April 2025
School of Pharmacy, Lanzhou University, Lanzhou 730000, PR China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China. Electronic address:
Objectives: Acute alcohol intoxication is characterized as high morbidity and mortality. To explore new chemicals to relieve ethanol intoxication, we tried to explore the activators of catalase (CAT), an enzyme responsible for oxidization of ethanol into acetaldehyde to accelerate ethanol removal.
Methods: We identified zanamivir, an antiviral agent, activated CAT in vitro after screening of clinical chemicals.
J Neuroimmune Pharmacol
February 2025
College of Pharmacy, Division of Pharmacology & Toxicology, The University of Texas at Austin, Austin, TX, 78712, USA.
Excessive alcohol use damages the brain, especially corticolimbic regions such as the hippocampus and rhinal cortices, leading to learning and memory problems. While neuroimmune reactivity is hypothesized to underly alcohol-induced damage, direct evidence of the causal role of microglia, brain-resident immune cells, in this process is lacking. Here, we depleted microglia using PLX5622 (PLX), a CSF1R inhibitor commonly used in mice, but rarely in rats, and assessed cell death following binge-like alcohol exposure in male rats.
View Article and Find Full Text PDFCureus
January 2025
Emergency Department, Kobe City Medical Center General Hospital, Kobe, JPN.
Trichloroethylene (TCE) is a hydrocarbon used commercially as a degreasing solvent. It has gradually become obsolete due to its carcinogenic properties, but many industries still use it given its cost-effectiveness. While there have been reports and studies regarding chronic exposures to TCE, very few acute cases of altered mental status requiring intensive care have been reported so far.
View Article and Find Full Text PDFAuris Nasus Larynx
April 2025
Department of Otolaryngology and Head and Neck Surgery, Tohoku University Graduate School of Medicine. 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi Prefecture 980-8574, Japan.
Objectives: Ethanol consumption may lead to various symptoms depending on its concentration in the blood. Acute ethanol intoxication is a major risk factor for bolus -aspiration; however, studies on the effects of acute ethanol intoxication on swallowing are lacking. Therefore, we investigated the effect of acute ethanol intoxication on mice using the videofluoroscopic swallowing study (VFSS) methodology.
View Article and Find Full Text PDFAnnu Rev Pharmacol Toxicol
January 2025
Department of Pharmacology, Addiction Science, and Toxicology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee, USA; email:
Toluene intoxication constitutes a persistent public health problem worldwide. While most organs can be damaged, the brain is a primary target whether exposure is accidental, occupational, or recreational. Interventions to prevent/revert brain damage by toluene are curtailed by the scarce information on the molecular targets and mechanisms mediating toluene's brain toxicity and the common exposure to other neurotoxins and/or coexistence of neurological/psychiatric disorders.
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