AI Article Synopsis
- Research has largely overlooked the changes in dendritic cells (DCs) after they interact with T cells during immune responses, focusing more on T cell activation instead.
- The study reveals that these postsynaptic DCs experience shifts in their gene expression and epigenetic marks, including modifications to DNA accessibility and histone methylation.
- It highlights that postsynaptic DCs show increased efficiency in migrating toward the chemokine CCL19 and better homing to lymph nodes, indicating significant functional changes following their engagement with T cells.
Article Abstract
Understanding the fate of dendritic cells (DCs) after productive immune synapses (postsynaptic DCs) with T cells during antigen presentation has been largely neglected in favor of deciphering the nuances of T cell activation and memory generation. Here, we describe that postsynaptic DCs switch their transcriptomic signature, correlating with epigenomic changes including DNA accessibility and histone methylation. We focus on the chemokine receptor as a proof-of-concept gene that is increased in postsynaptic DCs. Consistent with our epigenomic observations, postsynaptic DCs migrate more efficiently toward CCL19 in vitro and display enhanced homing to draining lymph nodes in vivo. This work describes a previously unknown DC population whose transcriptomics, epigenomics, and migratory capacity change in response to their cognate contact with T cells.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857677 | PMC |
| http://dx.doi.org/10.1126/sciadv.abb9965 | DOI Listing |
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