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Specificity of the Point-of-Care Urine Strip Test for Schistosoma Circulating Cathodic Antigen (POC-CCA) Tested in Non-Endemic Pregnant Women and Young Children. | LitMetric

AI Article Synopsis

  • The POC-CCA urine strip test, commonly used to diagnose Schistosoma mansoni in school-aged children, raises concerns about its effectiveness in adults and preschool-aged children since its performance in these groups hasn’t been thoroughly evaluated.
  • A study examined the specificity of the test in a group of healthy individuals, finding that pregnancy and being under nine months old significantly increased the rate of false positives.
  • Adjustments to the test’s pH level could potentially reduce false positives, suggesting that improvements in testing methods could enhance accuracy in vulnerable populations like pregnant women and young infants.

Article Abstract

The point-of-care urine based strip test for the detection of circulating cathodic antigen (POC-CCA) in schistosome infections is a frequently used tool for diagnosis and mapping of Schistosoma mansoni in school-aged children. Because of its ease of use, the test is increasingly applied to adults and preschool-aged children (PSAC), but its performance has not been specifically evaluated in these target groups. Recent observations have raised concerns about possible reduced specificity, in particular in pregnant women (PW) and PSAC. We thus explored specificity of the POC-CCA urine strip test (Rapid Medical Diagnostics, Pretoria, South Africa) in a non-endemic, nonexposed population of 47 healthy nonpregnant adults (NPAs), 52 PW, and 58 PSAC. A total of 157 urines were tested with POC-CCA, of which five (10.6%) NPAs, 17 (32.7%) PW, and 27 (46.5%) PSAC were positive. The highest scores were found in the youngest babies, with an infant of 9 months being the oldest positive case. On measuring pH, it appeared that all POC-CCA strongly positive urines were acidic (pH range 5-5.5), whereas addition of pH-neutral buffer to a subsample reversed the false positivity. We conclude that the POC-CCA test has reduced specificity in PW and infants younger than 9 months, but that the false positivity might be eliminated by modifications in the buffers used in the test.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8045634PMC
http://dx.doi.org/10.4269/ajtmh.20-1168DOI Listing

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