AI Article Synopsis
- - Giardiasis is a neglected disease linked to poverty, characterized by parasitic diarrhea, and current treatments are becoming less effective due to resistance.
- - Identifying unique essential kinases in the parasite's reduced kinome could reveal new drug targets, making it possible to repurpose existing kinase inhibitors for treatment.
- - Advances in pharmacokinetic modeling and new imaging techniques, along with CRISPR-interference methods, could speed up the development of better giardiasis therapies focused on inhibiting kinases.
Article Abstract
Giardiasis is a neglected parasitic diarrheal disease that is particularly associated with poverty. Current treatment options are limited in the face of growing resistance, but the reduced kinome of increases the likelihood of identifying nonredundant essential kinases as potential drug targets. Repurposing known and newly identified kinase inhibitors in drug development programs for novel giardiasis therapeutics could therefore be a cost-effective and time saving approach. Innovative improvements to physiologically-based pharmacokinetic modeling coupled with emerging imaging technologies and a CRISPR-interference method could accelerate progress toward the goal of more effective giardiasis therapeutics based on kinase inhibition.
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| http://dx.doi.org/10.1021/acsinfecdis.0c00919 | DOI Listing |
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