What Is Known And Objective: Drug-drug interactions can involve inhibition or induction of cell membrane transporters. Deinduction occurs after an inducing agent is stopped.
Case Summary: This case describes suspected P-glycoprotein (P-gp) deinduction by carbamazepine resulting in a slow viral response during treatment of chronic hepatitis C virus (HCV) infection. Evidence of deinduction occurred beyond clearance of carbamazepine and resulted in extension of HCV treatment.
What Is New: The understanding of the role P-gp transport plays in drug elimination is relatively new and evidence of P-gp deinduction is variable.
Conclusion: Clinicians should consider deinduction when starting and stopping medications involving strong inducers of P-gp transport proteins.
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| http://dx.doi.org/10.1111/jcpt.13374 | DOI Listing |
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