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http://dx.doi.org/10.1152/ajplung.00528.2020 | DOI Listing |
Adv Sci (Weinh)
December 2024
Department of Dermatology, Zhongshan Hospital of Fudan University, Shanghai, 200032, China.
Systemic sclerosis (SSc) is an autoimmune disease characterized by extensive skin and internal organ fibrosis. However, the mechanism underlying fibrosis remains unclear, and effective treatments for halting or reversing fibrosis are lacking. In this study, single-cell RNA sequencing is used to obtain a comprehensive overview of skin cells from patients with SSc and healthy controls.
View Article and Find Full Text PDFClin Transl Med
December 2024
Servei de Neurologia, Centre d´Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d´Hebron (VHIR), Hospital Universitari Vall d´Hebron, Universitat Autònoma de Barcelona (UAB), Barcelona, Spain.
J Inflamm Res
December 2024
Department of Pediatric Infectious Diseases, Medical University of Bialystok, Bialystok, Poland.
Background: Chitinase 3-like-1 (CHI3L1), also known as YKL-40, is a potential biomarker for neuroinflammatory conditions. It is upregulated in Alzheimer's disease, multiple sclerosis, and traumatic brain injury. However, its involvement in pediatric tick-borne encephalitis (TBE) has not been addressed yet.
View Article and Find Full Text PDFClin J Am Soc Nephrol
December 2024
Kidney Health Research Collaborative and Department of Medicine, University of California, San Francisco and San Francisco VA Health Care System, San Francisco, California.
Key Points: In diabetes and CKD, creatinine- and cystatin C–based eGFR has a strong inverse correlation with plasma TNF receptor 1, TNF receptor 2, and soluble urokinase-type plasminogen activator receptor. Higher plasma soluble TNF receptors 1 and 2 and soluble urokinase-type plasminogen activator receptor were each individually associated with mortality, independent of baseline kidney measures.
Background: Several plasma biomarkers of kidney health have been associated with CKD progression in persons with diabetes, but their associations with mortality risk have been largely unexplored.
Oncol Res
November 2024
Department of Anatomy, School of Basic Medicine, Guizhou Medical University, Key Laboratory of Human Brain Bank for Functions and Diseases of Department of Education of Guizhou Province, Guizhou Medical University, Guiyang, 550025, China.
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