The study aimed to assess the association between the key predictive foot structure variables and its loading paradigm in 625 school-aged children. Clinical appraisal relied primarily on having the plantar parts of their feet comprehensively assessed with Podoscan 2D Foot CAD, and a dynamometer platform, the research tools of choice widely acknowledged for their overall accuracy and reliability, with a view to determining the distribution of respective foot loads, as well as addressing both balance and gait issues. The Clarke's angle, Wejsflog index, length and width of the feet, regardless of gender, proved the key predictive variables for the foot-loading paradigm. Notably the Clarke's angle, construed the most sensitive variable in assessing flat-footedness, offered an extra added value in overall investigative effort. The actual design of the study protocol effectively complements a standard clinical assessment procedure, whereas by comprehensively addressing those variables, it is also believed to aid clinicians in gaining an extra, hands-on, diagnostic potential, so that any teenagers exposed to the highest risk of developing foot deformities could effectively be identified through pertinent screening tests, and consequently offered a task-oriented, therapeutic management, specifically aimed at preventing potential postural complaints in later life.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7854665PMC
http://dx.doi.org/10.1038/s41598-021-82475-yDOI Listing

Publication Analysis

Top Keywords

loading paradigm
8
school-aged children
8
key predictive
8
clarke's angle
8
foot
5
vulnerability foot's
4
foot's morphological
4
morphological structure
4
structure deformities
4
deformities caused
4

Similar Publications

Extracellular vesicles (EVs) are emerging as viable tools in cancer treatment due to their ability to carry a wide range of theranostic activities. This review summarizes different forms of EVs such as exosomes, microvesicles, apoptotic bodies, and oncosomes. It also sheds the light onto isolation methodologies, characterization techniques and therapeutic applications of all discussed EVs.

View Article and Find Full Text PDF

Oral Biomimetic Nanotherapeutics for Ulcerative Colitis Targeted Treatment by Repairing Intestinal Epithelial Barrier and Restoring Redox Homeostasis.

ACS Appl Mater Interfaces

January 2025

Department of Pharmaceutics, School of Pharmacy, Ningxia Medical University, No. 1160 Shengli South Street, Yinchuan 750004, PR China.

The structural disruption of intestinal barrier and excessive reactive oxygen/nitrogen species (RONS) generation are two intertwined factors that drive the occurrence and development of ulcerative colitis (UC). Synchronously restoring the intestinal barrier and mitigating excess RONS is a promising strategy for UC management, but its treatment outcomes are still hindered by low drug accumulation and retention in colonic lesions. Inspired by intestine colonizing bacterium, we developed a mucoadhesive probiotic -mimic entinostat-loaded hollow mesopores prussian blue (HMPB) nanotherapeutic (AM@HMPB@E) for UC-targeted therapy via repairing intestinal barrier and scavenging RONS.

View Article and Find Full Text PDF

As a recently discovered form of regulated cell death, ferroptosis has attracted much attention in the field cancer therapy. However, achieving considerably enhanced efficacy is often restricted by the overexpression of endogenous glutathione (GSH) in tumor microenvironment (TME). In this work, we report a ferroptosis-inducing strategy of GSH depletion and reactive oxygen species (ROS) generation based on a biodegradable copper-doped calcium phosphate (CaP) with L-buthionine sulfoximine (BSO) loading (denoted as BSO@CuCaP-LOD, BCCL).

View Article and Find Full Text PDF

AlgaeSperm: Microalgae-Based Soft Magnetic Microrobots for Targeted Tumor Treatment.

Small

January 2025

School of Mechanical Engineering and Automation, Beihang University, Beijing, 100191, China.

Magnetic microrobots are significant platforms for targeted drug delivery, among which sperm-inspired types have attracted much attention due to their flexible undulation. However, mass production of sperm-like soft magnetic microrobots with high-speed propulsion is still challenging due to the need of more reasonable structure design and facile fabrication. Herein, a novel strategy is proposed for large-scale preparation of microalgae-based soft microrobots with a fully magnetic head-to-tail structure, called AlgaeSperm with robust propulsion and chemo-photothermal performance.

View Article and Find Full Text PDF

Fast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission.

PLoS Comput Biol

January 2025

Department of Mechanical Engineering & Materials Science, Washington University, St. Louis, Missouri, United States of America.

Cell collectives, like other motile entities, generate and use forces to move forward. Here, we ask whether environmental configurations alter this proportional force-speed relationship, since aligned extracellular matrix fibers are known to cause directed migration. We show that aligned fibers serve as active conduits for spatial propagation of cellular mechanotransduction through matrix exoskeleton, leading to efficient directed collective cell migration.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!