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Assessing Metabolic Ageing via DNA Methylation Surrogate Markers: A Multicohort Study in Britain, Ireland and the USA.
Aging Cell
January 2025
MRC Centre for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Metabolomics and epigenomics have been used to develop 'ageing clocks' that assess biological age and identify 'accelerated ageing'. While metabolites are subject to short-term variation, DNA methylation (DNAm) may capture longer-term metabolic changes. We aimed to develop a hybrid DNAm-metabolic clock using DNAm as metabolite surrogates ('DNAm-metabolites') for age prediction.
View Article and Find Full Text PDF[Association between possible sarcopenia and risk for frailty in middle-aged and elderly adults in China: a cohort study].
Zhonghua Liu Xing Bing Xue Za Zhi
January 2025
Institute of Population Research/Chinese Center for Population Health and Development, Peking University, Beijing100871, China.
To assess the association between possible sarcopenia and the risk for frailty in middle-aged and elderly adults in China. A prospective cohort study design was used in this study. Data were from the China Health and Retirement Longitudinal Study during 2011-2018 and the baseline data in 2011, the follow up was conducted in 2013, 2015 and 2018, respectively.
View Article and Find Full Text PDFDevelopment and Validation of a Machine Learning Method Using Vocal Biomarkers for Identifying Frailty in Community-Dwelling Older Adults: Cross-Sectional Study.
JMIR Med Inform
January 2025
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Background: The two most commonly used methods to identify frailty are the frailty phenotype and the frailty index. However, both methods have limitations in clinical application. In addition, methods for measuring frailty have not yet been standardized.
View Article and Find Full Text PDFDiscrepancies between subjective and objective sleep assessments revealed by in-home electroencephalography during real-world sleep.
Proc Natl Acad Sci U S A
January 2025
International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
Sleep insufficiency and sleep disorders pose serious health challenges. This study aimed to determine the potential discrepancy between subjective and objective sleep assessments, including the latter made by physicians, by analyzing a 421-participant dataset in Japan comprising multiple nights of in-home sleep electroencephalogram (EEG) data and questionnaire responses on sleep habits or subjective experiences. We employed logistic regression models to examine which subjective and objective sleep parameters physicians are paying attention to when assessing sleep insufficiency, insomnia, sleep quality, and sleep apnea.
View Article and Find Full Text PDFDisparities in dolutegravir utilisation in children, adolescents and young adults (0-24 years) living with HIV. An analysis of the IeDEA Pediatric West African cohort.
BMJ Glob Health
January 2025
CERPOP, Toulouse, France.
Introduction: We describe the 24-month incidence of Dolutegravir (DTG)-containing antiretroviral treatment (ART) initiation since its introduction in 2019 in West Africa.
Methods: We included all patients aged 0-24 years on ART from nine clinics in Côte d'Ivoire (n=4), Ghana, Nigeria, Mali, Benin, and Burkina Faso. Baseline varied by clinic and was defined as date of first DTG prescription; patients were followed up until database closure/death/loss to follow-up (LTFU, no visit ≥7 months), whichever came first.
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