An efficient approach to a functionalized bicyclo[2.2.2]octan-2-one scaffold has been developed through a one-pot cascade process including amino acid involved successive Michael addition and decarboxylative-Mannich sequence. Starting from α,β-unsaturated ketones and amino acids, a series of desired products - and - were obtained with moderate yields. In addition, the tandem process was reasonably explained by the results of DFT calculations.
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