Objectives: To assess a baseline assessment using developed functional magnetic resonance imaging (fMRI) language paradigms for Arabic-speakers.
Methods: 24-healthy right-handed volunteers scanned on a 3.0 Tesla MRI machine. For fMRI, a BOLD-sensitive sequence used to measure signals over time across 6 language paradigms: rhyming (RH), semantic category generations (SCG), silent word generation (SWG), verb generation picture (VGp), verb generation word (VGw), and verb generation audio (VGa). fMRI data was analyzed using FMRIB Software Library (FSL).
Results: We found that VGa, SWG, VGw and VGp robustly activated language-related regions in the dominant hemisphere. RH and SCG failed to adequately define these activation regions but this may be related to the study's preliminary nature and limitations. After assessment of their validity, considerable activation of the inferior frontal gyrus during VGa, SWG, VGw and VGp suggests that these paradigms have the potential for localizing of Broca's area in native Arabic speakers.
Conclusion: Set of well adapted, and evidence-based, fMRI paradigms were established for Arabic-speakers to enable accurate and sufficient localization and lateralization of the language area. After validation, these paradigms may provide sequences for accurate localization of brain language areas, and could be used as a presurgical evaluation tool.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8015493 | PMC |
| http://dx.doi.org/10.17712/nsj.2021.1.20200012 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neural dynamics of social verb processing: An MEG study.
Soc Cogn Affect Neurosci
December 2024
Cognitive Neuroscience Center (CNC), University of San Andres, Buenos Aires, C1011ACC, Argentina.
Human vocabularies include specific words to communicate interpersonal behaviors, a core linguistic function mainly afforded by social verbs (SVs). This skill has been proposed to engage dedicated systems subserving social knowledge. Yet, neurocognitive evidence is scarce, and no study has examined spectro-temporal and spatial signatures of SV access.
View Article and Find Full Text PDFRehabilitation of post-stroke aphasia by a single protocol targeting phonological, lexical, and semantic deficits with speech output tasks: a randomized controlled trial.
Eur J Phys Rehabil Med
December 2024
Laboratory of Neuropsychology, Department of Neurorehabilitation Sciences, IRCCS Istituto Auxologico Italiano, Milan, Italy.
Background: The defective spoken output of persons with aphasia has anomia as a main clinical manifestation. Improving anomia is therefore a main goal of any language treatment.
Aim: This study assessed the effectiveness of a novel, 2-week, rehabilitation protocol (PHOLEXSEM), focused on PHonological, SEmantic, and LExical deficits, aiming at improving lexical retrieval, and, generally, spoken output.
This study investigates Navajo verbs produced by four children, ages 4;07 to 11;02, during conversations with their caretakers. Analyses of 1600 verbs demonstrate that the bisyllabic verb form, consisting of a verb stem and a portion of the prefix string, is the most common pattern produced by the children. This indicates that Navajo-speaking children use meaningful units of verbal morphology that do not necessarily adhere to the linguistic boundaries normally ascribed to the Navajo verb complex.
View Article and Find Full Text PDFAugmenting Verb-Naming Therapy With Neuromodulation Decelerates Language Loss in Primary Progressive Aphasia.
Am J Speech Lang Pathol
December 2024
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Purpose: The purpose of the study was to evaluate Verb Network Strengthening Treatment (VNeST) paired with the transcranial direct current stimulation (tDCS) of the left inferior frontal gyrus, which was compared to VNeST paired with a sham stimulation in primary progressive aphasia (PPA).
Method: A double-blind, within-subject, sham-controlled crossover design was used. Eight participants with PPA were enrolled.
Non-right-handedness, male sex, and regional, network-specific, ventral occipito-temporal anomalous lateralization in adults with a history of reading disability.
Cortex
November 2024
Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; Dyslexia Center, Department of Neurology and Psychiatry, UCSF Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Electronic address:
Based on historic observations that children with reading disabilities were disproportionately both male and non-right-handed, and that early life insults of the left hemisphere were more frequent in boys and non-right-handed children, it was proposed that early focal neuronal injury disrupts typical patterns of motor hand and language dominance and in the process produces developmental dyslexia. To date, these theories remain controversial. We revisited these earliest theories in a contemporary manner, investigating demographics associated with reading disability, and in a subgroup with and without reading disability, compared structural imaging as well as patterns of activity during tasks of verb generation and non-word repetition using magnetoencephalography source imaging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!