Background: Alzheimer's Disease (AD), a type of dementia that interferes with memory, thinking, and behavior is the most common type of dementia. As a result, it is a leading contributor to death and disability for those over the age of 65. Therefore, future nurses must have the knowledge and skills to manage patients with AD in any setting spanning the healthcare continuum.
Objective: The goal of this project was to evaluate perceptions of awareness, knowledge and sensitivity of future nurses concerning AD patients before and after participation in a simulated virtual reality dementia experience.
Design/participants: A quasi-experimental repeated measure pre-post design was used with a convenience sample of 163 undergraduate baccalaureate nursing students from three different courses at large public university in the Midwest.
Methods: Students were placed in teams of four to participate in a 45-minute interactive simulated virtual reality dementia experience. Each session started with a 15-minute team pre-briefing session, followed by a 10-minute individual simulation, which was then followed by a 30-minute team debriefing session facilitated by faculty using the Plus/ Delta debriefing technique. The Dementia Attitudes Scale (DAS), The Knowledge About Memory Loss and Care Test (KAML-C), and the Healthcare Tour Survey were administered pre/post participation. Qualitative data was also collected from student reflections.
Results: Statistically significant changes (p < 0.001) were noted in the pre/post DAS survey and the Healthcare Tour Survey. No significant change was noted on the KAML-C, although there was a trend towards improvement. No differences were noted between courses on any of the surveys.
Conclusion: Using a virtual reality dementia experience proved to be a valuable strategy to increase student perceptions of awareness, knowledge, and sensitivity of AD. Further exploration is warranted to establish how these may be further facilitated to translate into improved care for those with AD.
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http://dx.doi.org/10.1016/j.nedt.2021.104764 | DOI Listing |
J Comput Chem
January 2025
Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, New South Wales, Australia.
Phosphodiesterase 5 (PDE5) inhibitors have shown great potential in treating Alzheimer's disease by improving memory and cognitive function. In this study, we evaluated fluspirilene, a drug commonly used to treat schizophrenia, as a potential PDE5 inhibitor using computational methods. Molecular docking revealed that fluspirilene binds strongly to PDE5, supported by hydrophobic and aromatic interactions.
View Article and Find Full Text PDFNat Genet
January 2025
Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
Gene expression quantitative trait loci are widely used to infer relationships between genes and central nervous system (CNS) phenotypes; however, the effect of brain disease on these inferences is unclear. Using 2,348,438 single-nuclei profiles from 391 disease-case and control brains, we report 13,939 genes whose expression correlated with genetic variation, of which 16.7-40.
View Article and Find Full Text PDFBMC Geriatr
January 2025
Department of Neurology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250014, China.
Objective: This study aims to investigate the influence of social determinants of health (SDoH) on cognitive performance.
Methods: This study surveyed a sample of older adults aged 60 years and older from the 2011-2014 cohort of participants in the U.S.
Cells
January 2025
Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.
Huntington's disease (HD) is an inherited neurodegenerative disease characterized by uncontrolled movements, emotional disturbances, and progressive cognitive impairment. It is estimated to affect 4.3 to 10.
View Article and Find Full Text PDFJ Contemp Dent Pract
September 2024
Bibliometrics, Evidence Evaluation and Systematic Reviews (BEERS) Group, Human Medicine Career, Universidad Científica del Sur, Lima, Peru, Phone: +5113171023, e-mail:
Aim: To perform a bibliometric study of periodontal disease and Alzheimer's disease (AD) focusing on trends, collaborative efforts, and emerging patterns.
Materials And Methods: From January 2018 to May 2024, an observational study was carried out utilizing metadata extracted from the Scopus database. A search methodology, specifically designed for this database, was developed using MeSH terms combined with Boolean operators such as "AND" and "OR".
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