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Comprehensive histopathological analysis of gastric cancer in European and Latin America populations reveals differences in PDL1, HER2, p53 and MUC6 expression.
Gastric Cancer
January 2025
Department of Medical Oncology, Hospital Clinico Universitario, INCLIVA, Biomedical Research Institute, University of Valencia, Avenida Menendez Pelayo nro 4 accesorio, Valencia, Spain.
Introduction: Gastric cancer (GC) burden is currently evolving with regional differences associated with complex behavioural, environmental, and genetic risk factors. The LEGACy study is a Horizon 2020-funded multi-institutional research project conducted prospectively to provide comprehensive data on the tumour biological characteristics of gastroesophageal cancer from European and LATAM countries.
Material And Methods: Treatment-naïve advanced gastroesophageal adenocarcinoma patients were prospectively recruited in seven European and LATAM countries.
The impact of spillover and crossover effects of job stressors on pregnancy rates in couples undergoing in vitro fertilization treatments.
J Assist Reprod Genet
January 2025
Meir Medical Center, Kfar Saba, Israel.
Purpose: Studies have shown mixed findings regarding the impact of stress on the success of fertility treatments. To the best of our knowledge, stress in the context of the workplace has not been investigated to date in relation to the success of fertility treatments. This research investigates the impact of work-related stress and emotional exhaustion experienced by both partners on in vitro fertilization (IVF) treatment outcomes.
View Article and Find Full Text PDFSpillover effect of children's education on parental physical functioning over the life course.
Sci Rep
January 2025
School of Public Administration, South China University of Technology, Guangzhou, China.
Parental well-being is linked to the life chances of adult children in later life. Despite accumulated knowledge on the role of children's education on parental longevity in developed contexts, it remains unknown how children's education may influence the trajectories of parental physical well-being over the aging process, particularly in developing contexts. Using a growth curve model and four-wave data from the China Health and Retirement Longitudinal Study, this study examines the association between children's education and parental physical functioning trajectories as parents age.
View Article and Find Full Text PDFCiliary muscle traction during accommodation is able to induce optic nerve head deformation.
Eye (Lond)
January 2025
Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing, China.
Objectives: To use finite element (FE) modeling and in vivo optical coherence tomography (OCT) imaging to explore the effect of ciliary muscle traction on optic nerve head (ONH) deformation during accommodation.
Methods: We developed a FE model to mimic the ciliary muscle traction during accommodation, and varied the stiffness of the sclera, choroid, Bruch's membrane (BM), prelaminar neural tissue and lamina cribrosa (LC) to assess their effects on accommodation-induced ONH strains. To validate the FE model, OCT images of the right eyes' ONHs from 20 subjects (25 ± 1.
Self-compassion as a mediator of attachment anxiety, attachment avoidance, and complex PTSD in college students with adverse childhood experiences.
Sci Rep
January 2025
Faculty of Social Sciences and Liberal Arts, UCSI University, 56000, Kuala Lumpur, Malaysia.
Given the significant prevalence of adverse childhood experiences (ACEs) and their detrimental impact on mental health, this study examines the relationship between attachment anxiety, attachment avoidance, and complex post-traumatic stress disorder (CPTSD) among college students with ACEs, emphasizing the mediating role of self-compassion (SC). A sample of 32,388 students from Kunming, China completed a survey including the Revised Adverse Childhood Experiences Questionnaire (ACEQ-R), the Adult Attachment Scale (AAS), the International Trauma Questionnaire (ITQ), and the Self-Compassion Scale-Short Form (SCS-SF). Among the participants, 3,896 reported at least one ACE.
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