Supramolecular capsules are nanoscale containers useful for the study of molecular behavior in confined spaces. They offer practical applications in catalysis, molecular transport, drug delivery, and materials science. Self-assembly has proven to be an effective approach in constructing supramolecular capsules and a variety of well-known noncovalent interactions including hydrogen bonding, metal coordination and ionic interactions have been deployed. Bowl-shaped cavitand structures built up from resorcinarenes have particular advantages for the construction of supramolecular capsules, and this highlight discusses the unconventional self-assembly of molecular capsules held together by halogen and chalcogen bonds.
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