Biosynthesis of azaphilones: a review.

Nat Prod Rep

Normandie Univ., CNRS, UNIROUEN, INSA Rouen, COBRA (UMR 6014 & FR 3038), 76000 Rouen, France.

Published: June 2021

AI Article Synopsis

  • Azaphilones are pigments produced by fungi with a complex chemical structure, gaining attention for their potential uses in various industries including food, cosmetics, and pharmaceuticals.
  • Research on their biosynthesis is evolving, with recent advances in genomic techniques helping to clarify how these compounds are produced in fungi.
  • This review focuses specifically on the genomic insights into azaphilonoid biosynthesis, marking the first comprehensive look at this topic from a genomic perspective.

Article Abstract

Covering up to 2020 Azaphilones are fungal polyketide pigments bearing a highly oxygenated pyranoquinone bicyclic core; they are receiving a great deal of increasing research interest for their applications in the agroalimentary, dyeing, cosmetic, printing and pharmaceutical industries. Their biosynthetic pathways are not fully elucidated; however, thanks to recent genomic approaches combined with the increasing genome sequencing of fungi, some of these pathways have been recently unveiled. This is the first review on the biosynthesis of azaphilonoids adressed from a genomic point of view.

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http://dx.doi.org/10.1039/d0np00080aDOI Listing

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