Microbial Transformation of Broussochalcones A and B by .

Broussochalcones A (BCA, ) and B (BCB, ) are major bioactive constituents isolated from , a polyphenol-rich plant belonging to the family Moraceae. Due to their low yields from natural sources, BCA () and BCB () were prepared synthetically by employing Claisen-Schmidt condensation, and these were used as substrates for microbial transformation to obtain novel derivatives. Microbial transformation of BCA () and BCB () with the endophytic fungus KCCM 60332 yielded 10 previously undescribed chalcones (- and -). Their structures were established based on the spectroscopic methods. The cytotoxicity of BCA (), BCB (), and their metabolites (- and -) was determined by human cancer cell lines A375P, A549, HT-29, MCF-7, and HepG2, with shown to be most cytotoxic.