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We propose a micromixer for obtaining better efficiency of vortex induced electroosmotic mixing of non-Newtonian bio-fluids at a relatively higher flow rate, which finds relevance in many biomedical and biological applications. To represent the rheology of non-Newtonian fluid, we consider the Carreau model in this study, while the applied electric field drives the constituent components in the micromixer. We show that the spatial variation of the applied field, triggered by the topological change of the bounding surfaces, upon interacting with the non-uniform surface potential gives rise to efficient mixing as realized by the formation of vortices in the proposed micromixer. Also, we show that the phase-lag between surface potential leads to the formation of asymmetric vortices. This behavior offers better mixing performance following the appearance of undulation on the flow pattern. Finally, we establish that the assumption of a point charge in the paradigm of electroosmotic mixing, which is not realistic as well, under-predicts the mixing efficiency at higher amplitude of the non-uniform zeta potential. The inferences of the present analysis may guide as a design tool for micromixer where rheological properties of the fluid and flow actuation parameters can be simultaneously tuned to obtain phenomenal enhancement in mixing efficiency.
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http://dx.doi.org/10.1002/elps.202000225 | DOI Listing |
Electrophoresis
October 2024
Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida, USA.
Glucagon plays a crucial role in regulating glucose homeostasis; unfortunately, the mechanisms controlling its release are still unclear. Capillary electrophoresis (CE)- and fluorescence anisotropy (FA)-immunoassays (IA) have been used for online measurements of hormone secretion on microfluidic platforms, although their use in glucagon assays is less common. We set out to compare a glucagon-competitive IA using these two techniques.
View Article and Find Full Text PDFJ Sep Sci
February 2024
Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, P. R. China.
In this work, the potential synergetic effect between deep eutectic solvents and an antibiotic chiral selector (clindamycin phosphate) for enantioseparation was investigated in capillary electrophoresis. We synthesized a series of deep eutectic solvents with choline chloride as hydrogen bond acceptor and three α-hydroxyl acids (l-lactic acid, l-malic acid, and l-tartaric acid) as hydrogen bond donors. Compared to the single clindamycin phosphate separation system, significantly improved separations of model drugs were observed in several synergetic systems.
View Article and Find Full Text PDFMicromachines (Basel)
December 2023
Computer Center, The Second Hospital of Dalian Medical University, Dalian 116023, China.
Micromixers play a crucial role as essential components in microfluidic analysis systems. This paper introduces a novel micromixer designed by harnessing electrokinetic vortices arising on the surface of a Janus droplet within a microchannel. The Janus droplet is characterized by different polarities of charges on its two sides (upstream part and downstream part).
View Article and Find Full Text PDFEnviron Monit Assess
October 2023
Department of Water Resources Engineering, College of Engineering, University of Baghdad, Baghdad, Iraq.
Remediation of arsenic-contaminated soil by the technique of electro-kinetic using various enhanced conditions is the thrust of this study. Many tests were performed with different operating conditions, such as the electrodes solution (tap water) with a variable pH at (2, 5, and 8). Cyclodextrin (10% hydroxypropyl-beta-cyclodextrin, or HPCD) has been used as an activating agent that helps enhance this process of soil arsenic clean-up.
View Article and Find Full Text PDFSci Rep
September 2023
Department of Mathematics and Computer Science, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
The essential purpose of this study is to discuss the impact of time-periodic variations on mixed convection heat transfer for MHD Eyring-Powell nanofluid. The fluid flows through a non-Darcy porous medium over an infinite vertical plate. The effects of viscous dissipation, Ohmic dissipation, electro-osmosis force, heat source, thermal radiation, Dufour feature, and chemical reaction are presumed.
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