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Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy. | LitMetric
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Intact Human Immunodeficiency Virus (HIV) Reservoir Estimated by the Intact Proviral DNA Assay Correlates With Levels of Total and Integrated DNA in the Blood During Suppressive Antiretroviral Therapy.

Emmanouil Papasavvas Livio Azzoni Brian N Ross Matthew Fair Zhe Yuan Kwasi Gyampoh Agnieszka Mackiewicz Amanda C Sciorillo Amelie Pagliuzza Steven M Lada Guoxin Wu Shih Lin Goh Carolyn Bahnck-Teets Daniel J Holder Paul D Zuck Mohammad Damra Kenneth M Lynn Pablo Tebas Karam Mounzer Jay R Kostman

Clin Infect Dis

Wistar Institute, Philadelphia, Pennsylvania, USA.

Published: February 2021

Accurate characterization of the human immunodeficiency virus (HIV) reservoir is imperative to develop an effective cure. HIV was measured in antiretroviral therapy-suppressed individuals using the intact proviral DNA assay (IPDA), along with assays for total or integrated HIV DNA, and inducible HIV RNA or p24. Intact provirus correlated with total and integrated HIV.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850524PMC
http://dx.doi.org/10.1093/cid/ciaa809DOI Listing

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