AI Article Synopsis
- - Immunization with a mix of insect cell lysate and baculovirus containing the recombinant spike protein of porcine epidemic diarrhea virus (PEDV) led to strong neutralizing antibody responses in mice and piglets.
- - Despite the antibody response, piglets vaccinated with this mixture showed worse disease symptoms and increased virus replication when exposed to PEDV after vaccination.
- - These findings highlight a new challenge in PEDV vaccine research, offering crucial insights for developing coronavirus vaccines in general.
Article Abstract
Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7851141 | PMC |
| http://dx.doi.org/10.1038/s41541-021-00283-x | DOI Listing |
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