AI Article Synopsis
- After screening for anti-angiogenic activity, n-butanol was extracted from the ethanol extract of Staurogyne concinnula and further purified, revealing four new triterpenoid saponin derivatives, along with one known compound, baptisiasaponin I.
- The structures of the compounds were identified using advanced techniques like ESI-MS and NMR.
- Biological tests indicated that baptisiasaponin I had strong anti-angiogenic effects and worked by inhibiting specific signaling pathways and their related proteins, MMP2 and MMP9.
Article Abstract
After anti-angiogenic activity screening, the potential n-butanol layer partitioned from the ethanol extract of Staurogyne concinnula was conducted. Further purification by Diaion HP20 column and preparative HPLC chromatography, four undescribed triterpenoid saponin derivatives, along with the known baptisiasaponin I, and four known phenylpropanoid glycosides were isolated and characterized from n-butanol layer. The structures of isolated compounds were elucidated by ESI-MS, 1D, and 2D MNR data. Biological evaluation revealed that baptisiasaponin I possessed significant anti-angiogenic effects (IC 4.0 ± 0.2 μM). Further mechanism of action of baptisiasaponin I by inhibition of integrin/FAK/paxillin signaling pathway and its downstream effectors as MMP2 and MMP9 are also presented.
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| http://dx.doi.org/10.1016/j.phytochem.2021.112666 | DOI Listing |
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Article Synopsis
- After screening for anti-angiogenic activity, n-butanol was extracted from the ethanol extract of Staurogyne concinnula and further purified, revealing four new triterpenoid saponin derivatives, along with one known compound, baptisiasaponin I.
- The structures of the compounds were identified using advanced techniques like ESI-MS and NMR.
- Biological tests indicated that baptisiasaponin I had strong anti-angiogenic effects and worked by inhibiting specific signaling pathways and their related proteins, MMP2 and MMP9.
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