Magnetic reduced graphene oxide as a nano-vehicle for loading and delivery of curcumin.

Magnetic nanoparticles have been widely used in the field of nanomedicine as drug delivery vehicles for targeted imaging-guided and controlled drug uptake and release actions. In this work, the loading of curcumin on FeO/rGO nanocomposites and their interaction mechanism were investigated by multispectral methods including resonance light scattering (RLS), atomic force microscopy (AFM), circular dichroism (CD) and Fourier transform infrared (FT-IR). Results revealed that the drug loading was a complex process which is not governed by a simple adsorption. The interactions of vitro human serum albumin (HSA) with free curcumin and/or curcumin-FeO/rGO complex have been studied. Outcomes from the fluorescence quenching showed that the binding constant of curcumin to HSA increased significantly in the presence of FeO/rGO, confirming the enhanced effect of FeO/rGO besides its low toxicity towards HSA. Findings from this work verified that FeO/rGO nanocomposite has a promising potential as a good drug loading carrier that can be used and broad range of therapies.