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Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival. | LitMetric

Primary diffuse large B-cell lymphoma of the major salivary glands: Increasing incidence and survival.

Am J Otolaryngol

Department of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, United States of America.

Published: October 2021

AI Article Synopsis

Article Abstract

Background: Diffuse Large B-Cell Lymphoma (DLBCL) of the major salivary glands is a rare high-grade malignancy that often presents with vague symptoms. This study aimed to evaluate its incidence and prognosis on a population level.

Methods: The Surveillance, Epidemiology, and End Results database was queried for cases of major salivary gland DLBCL.

Results: 896 patients had DLBCL affecting the parotid gland (78.3%) or submandibular gland (19.8%). The incidence was increasing at 1.5% (P = 0.005) per year from 1973 to 2016. 24.4% of patients underwent parotidectomy, 16% had biopsy, and the remaining provided no details of diagnostic method. Five-year disease-specific survival increased from 59.8% to 84.0%. Late-stage disease (HR = 1.7, P = 0.003) and female sex (HR = 2.1, P = 0.018) were associated with increased risk of mortality.

Conclusion: Despite the rising incidence of major salivary gland DLBCL, chemotherapy and radiation treatment has resulted in increasingly favorable survival outcomes. The otolaryngologist - head and neck surgeon continues to play a critical role in establishing the diagnosis of salivary gland DLBCL.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.amjoto.2021.102938DOI Listing

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