AI Article Synopsis
- The study aimed to confirm whether low IgG indices in hepatitis C virus (HCV) reactive samples correlate with negative RNA tests using current testing methods.
- Researchers analyzed 2368 IgG-reactive samples, grouping them into Low, Medium, and High IgG indices, and found that while median viral loads were similar across groups, the Low group had a higher percentage of samples with low viral loads.
- The findings support the Centers for Disease Control's recommendation to test all HCV IgG-reactive samples for HCV RNA, as some low-index samples still tested positive for the virus.
Article Abstract
Centers for Disease Control guidelines recommend hepatitis C virus (HCV) RNA testing of all HCV IgG-reactive samples, although earlier studies found that IgG-reactive samples with low indices were negative in qualitative RNA assays. To determine if previous study results could be confirmed using current real-time RT-PCR technology, we investigated the relationship between HCV IgG index (Ortho VITROS) and quantitative HCV RNA results (cobas HCV) for 2368 consecutive IgG-reactive sera. Results were segregated into Low (1.00-16.0), Medium (16.1-30.0), and High (>30.0) IgG index groups. Although median viral load (VL) of RNA-positive samples was similar in all 3 groups, the percentage with low VL (1.18-4.16 log IU/mL) was increased for the Low group. Further analysis of the Low group revealed that 23 of 370 (6%) samples with IgG indices ≤8.00 were RNA-positive, and 13/23 (57%) had low VL. Our analysis supports the Centers for Disease Control recommendation to test all HCV IgG-reactive sera for HCV RNA.
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| http://dx.doi.org/10.1016/j.diagmicrobio.2021.115311 | DOI Listing |
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