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Safety and Effectiveness of a 4-Week Diet on Low-Carb Ready-to-Eat Ketogenic Products as Preoperative Care Treatment in Patients Scheduled for Metabolic and Bariatric Surgery.
Nutrients
November 2024
Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Italy.
Before metabolic and bariatric surgery (MBS), moderate weight loss and liver left lateral section (LLLS) volume reduction are desirable. Low-carb ketogenic diet-induced weight loss before MBS has been shown to have beneficial effects on the reduction in body weight (BW) and LLLS. However, the nutritional protocol of low-carb ketogenic diet may be hard to keep for prolonged periods due to the lack of sweet taste.
View Article and Find Full Text PDFHome- vs Office-Based Narrowband UV-B Phototherapy for Patients With Psoriasis: The LITE Randomized Clinical Trial.
JAMA Dermatol
December 2024
Department of Dermatology, University of Utah School of Medicine, Salt Lake City.
Article Synopsis
- The study compares the effectiveness of home-based vs. office-based phototherapy for psoriasis, highlighting that while office therapy is cost-effective, it’s often hard to access compared to the more patient-preferred home therapy, which lacks sufficient clinical data, especially for those with darker skin.
- Conducted across 42 dermatology practices in the US, the trial involved 783 participants aged 12 and older with psoriasis, who were randomly assigned to either home or office phototherapy for 12 weeks, followed by another 12 weeks of observation.
- Results showed that home phototherapy led to better skin clearance and quality of life improvements, with 32.8% of participants achieving clear skin compared to
Impact of Disease Burden of Patients with Psoriasis on Biologic Therapy Switching: Real-World Evidence from the CorEvitas Psoriasis Registry.
Dermatol Ther (Heidelb)
October 2024
CorEvitas, LLC, Waltham, MA, USA.
Introduction: Due to variable psoriasis symptoms, disease progression, and individual responses to therapy, patients may start, stop, or switch biologic therapies. Real-world data on the associated disease burden of patients with psoriasis who do and do not switch biologics are incomplete.
Methods: This study compared disease burden among patients from the CorEvitas Psoriasis Registry (July 2017-December 2021) who switched biologics and those who did not within 4-12 months following initiation.
Diagnosis and management of heterotopic intramural pregnancy after in vitro fertilization: an eight-case series.
Ultraschall Med
August 2024
Imaging Department, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha City, China.
Article Synopsis
- The study looked at how ultrasound can help diagnose and treat a rare type of pregnancy called heterotopic intramural pregnancy (HIMP), where an embryo grows in the wall of the uterus after an embryo transfer.
- Eight women were included in the study, and most were diagnosed correctly through ultrasound; many had successful pregnancies with healthy babies.
- The researchers suggest that using only one embryo for transfer can lower the chance of getting HIMP, and that careful monitoring can help manage these pregnancies effectively.
Deucravacitinib onset of action and maintenance of response in phase 3 plaque psoriasis trials.
J Dermatolog Treat
December 2024
Oregon Medical Research Center, Portland, OR, USA.
Aim: In the global phase 3 POETYK PSO-1 and PSO-2 trials, significantly greater proportions of deucravacitinib-treated patients met the coprimary endpoints (PASI 75, sPGA 0/1) at Week 16 versus placebo or apremilast-treated patients. This analysis evaluated onset of action and maintenance of response in patients randomized to deucravacitinib and placebo only.
Methods: Adults with moderate to severe plaque psoriasis at baseline were randomized 1:2:1 to oral placebo, deucravacitinib, or apremilast.
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