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Ligand efficiency indices for effective drug discovery: a unifying vector formulation. | LitMetric

Ligand efficiency indices for effective drug discovery: a unifying vector formulation.

Expert Opin Drug Discov

Department of Pharmaceutical Sciences, Institute of Tuberculosis Research, Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, Illinois.

Published: July 2021

AI Article Synopsis

Article Abstract

Introduction: The area of ligand efficiency indices (LEIs) in drug discovery has developed significantly since the initial publications nearly 20 years ago. A large number of different LEIs have been defined and applied with certain degrees of success and acceptance in the community. An overall view emphasizing more the common elements than the differences is needed.

Areas Covered: In this review, the author accentuates the numerical and algebraic relationships among the different LEIs and proposes the notion of 'ligand efficiency index' (LEI) as a vector variable comprising two interrelated components that provide 'direction' and 'distance' along the drug discovery process. The same concept had been suggested before relating to the graphical representation of the content of Structure-Activity Databases (SAR-Databases).

Expert Opinion: The extension of the concept of ligand efficiency from a scalar to a vector will help to unify the different formulations by emphasizing the relationship among the different variables. It should also provide an algebraically robust framework to critically assess the value of LEIs, and to incorporate them routinely in various workflows and protocols. Only cautious and rigorous testing by the community could provide a definitive proof of their possible value as reliable optimization variables in drug discovery.

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Source
http://dx.doi.org/10.1080/17460441.2021.1884065DOI Listing

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