AI Article Synopsis
- The oleoresin from Brazilian Copaifera species contains copalic acid and sesquiterpenes, exhibiting strong anti-inflammatory properties in rat models.
- Administration of the oleoresin at doses between 0.70 to 2.69 ml/kg effectively reduced edema and granuloma formation, showing effects similar to a standard anti-inflammatory drug.
- The estimated lethal dose (LD50) for the oleoresin in rats is around 3.79 ml/kg, indicating its relative safety compared to its therapeutic effects.
Article Abstract
The oleoresin from Brazilian Copaifera species yielded copalic acid and sesquiterpenes and showed marked anti-inflammatory activity using various experimental models in rats. The oleoresin significantly inhibited carrageenin-induced pedal edema following oral doses from 0.70 to 2.69 ml/kg, but was somewhat less effective than 50 mg/kg calcium phenylbutazone. Repeated administration of the oleoresin at a dose of 1.26 ml/kg for a 6-day period reduced granuloma formation with a response comparable to that of 20 mg/kg of calcium phenylbutazone. This same dose of oleoresin also reduced the vascular permeability to intracutaneous histamine. The LD50 value of the oleoresin in rats was estimated to be 3.79 (3.21-4.47) ml/kg.
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| http://dx.doi.org/10.1016/0378-8741(88)90235-8 | DOI Listing |
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