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| http://dx.doi.org/10.3324/haematol.2020.266627 | DOI Listing |
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Cerebral iron accumulation in multiple sclerosis: Pathophysiology and therapeutic implications.
Autoimmun Rev
January 2025
Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Italy.
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system characterized by demyelination, neuroinflammation, and neurodegeneration. Recent studies highlight the role of cerebral iron (Fe) accumulation in exacerbating MS pathophysiology. Fe, essential for neural function, contributes to oxidative stress and inflammation when dysregulated, particularly in the brain's gray matter and demyelinated lesions.
View Article and Find Full Text PDFFerroptosis: A Key Driver in Atherosclerosis Progression and Arterial Disease.
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Department of Cardiology, Royal Gwent Hospital, NP20 2UB Newport, UK.
Atherosclerosis (AS) is a growing global health epidemic and is the leading cause of cardiovascular health problems, including ischemic stroke, coronary artery disease, and peripheral vascular disease. Despite extensive research on the underlying mechanisms of AS, iron remains an under-investigated mediator in the atherosclerotic process. Iron's involvement in AS is primarily linked to the iron-induced programmed cell death process known as ferroptosis.
View Article and Find Full Text PDFBreast Ironing from the Perspective of Transcultural Nursing by Madeleine Leininger: A Narrative Review.
Nurs Rep
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Department of Nursing, Faculty of Nursing, University of Valladolid, Av. Ramón y Cajal, 7, 47005 Valladolid, Spain.
(1) Background: This article addresses the harmful traditional practice of breast ironing, which primarily affects girls and adolescents in several countries, particularly in Cameroon. The practice involves applying heat and pressure to developing breasts to delay their growth, with the goal of protecting girls from sexual abuse, early pregnancy, and forced marriages. While culturally accepted, breast ironing has severe physical, psychological, and social consequences, including damage to mammary glands, pain, infections, and potential long-term health complications.
View Article and Find Full Text PDFDevelopment of a sulfidized zerovalent iron-geopolymer composite for the reductive immobilization of ReO.
J Environ Manage
December 2024
Division of Environmental Science and Engineering (DESE), Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea; Division of Advanced Nuclear Engineering (DANE), Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea. Electronic address:
A geopolymer waste form has become a suitable approach for the immobilization of the volatile technetium (Tc) due to the low curing temperature (<60 °C). However, the low retention and the high mobility of the anionic technetium (TcO) remain challenging due to the charge repulsion stemming from the negative charges of the geopolymer surface and the anionic TcO. Herein, a geopolymer composite containing sulfidized nanoscale zerovalent iron (S-nZVI) was developed to reductively immobilize ReO (used as a non-radioactive surrogate for TcO).
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Cochrane Database Syst Rev
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Medical Research Council Clinical Trials Unit, Institute for Clinical Trials and Methodology, University College London, London, UK.
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