Consecutive Silver(I) Ion Incorporation into Oligonucleotides containing Cytosine-Cytosine Mispairs.

Chempluschem

Department of Physical and Environmental Sciences, University of Toronto Scarborough, Address 11265 Military Trail, Toronto, M1C 1A4, Canada.

Published: February 2021

Invited for this month's cover is the group of Prof. Heinz-Bernhard Kraatz from the University of Toronto, Canada. The cover picture shows the consecutive incorporation of Ag ions into a DNA duplex containing adjacent C-C mispairs. Read the full text of the article at 10.1002/cplu.202000607.

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http://dx.doi.org/10.1002/cplu.202000692DOI Listing

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Consecutive Silver(I) Ion Incorporation into Oligonucleotides containing Cytosine-Cytosine Mispairs.

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Department of Physical and Environmental Sciences, University of Toronto Scarborough, Address 11265 Military Trail, Toronto, M1C 1A4, Canada.

Invited for this month's cover is the group of Prof. Heinz-Bernhard Kraatz from the University of Toronto, Canada. The cover picture shows the consecutive incorporation of Ag ions into a DNA duplex containing adjacent C-C mispairs.

View Article and Find Full Text PDF

Consecutive Silver(I) Ion Incorporation into Oligonucleotides containing Cytosine-Cytosine Mispairs.

Chempluschem

February 2021

Department of Physical and Environmental Sciences, University of Toronto Scarborough, 11265 Military Trail, Toronto, M1 C 1 A4, Canada.

Herein, the consecutive incorporation of Ag ion into the dsDNA containing adjacent C-C mispairs is demonstrated. The melting temperature (T ) was 8  C higher for DNA containing three C-C mispairs upon the addition of three Ag ions as compared to the Ag -free DNA, and no T was obtained in the presence of excess Ag ion, indicating a stable bridging of C-Ag -C upon the incorporation of the stoichiometric amount of Ag per C-C mispair. The circular dichroism (CD) spectra of the dsDNA showed a negative peak at ∼270 nm in the presence of excess Ag , implying that significant structural changes and a potential aggregation of DNA occurred.

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