AI Article Synopsis
- Atherogenesis involves endothelial dysfunction, lipid metabolism issues, and inflammation, with a significant role played by the inflammatory responses of various cellular components.
- The study focused on the impact of genetic variations in the NF-kB pathway on coronary artery disease, analyzing patients from a heavily industrialized area in Russia using specific genetic testing methods.
- Findings indicate that certain genetic polymorphisms in IL18R1 and IL18RAP are linked to higher risks of myocardial infarction and severe atherosclerosis, suggesting that monitoring these genetic factors could be crucial for understanding and preventing coronary events.
Article Abstract
Background: Atherogenesis is mainly determined by endothelial dysfunction, lipid metabolism disorders and inflammation. The atherogenesis-related inflammatory process is a complex interaction between serum blood lipoproteins, inflammatory cells, endothelial and smooth muscle cells and extracellular matrix; the role of chronic inflammation in atherogenesis was proposed.
Material And Methods: A pathogenetic role of polymorphism in NF-kB pathway genes in coronary artery disease and associated pathological conditions has been suggested in a case-control retrospective study. 260 coronary artery disease patients permanently living in a large industrial region of Russian Federation (Kemerovo region) were recruited in the study. We examined nine single nucleotide polymorphisms in IL18, IL18R1 and IL18RAP genes by polymerize chain reaction; and serum blood level of IL18 by enzyme-linked immunosorbent assay.
Results: Polymorphic variants rs13015714 (IL18R1) and rs917997 (IL18RAP) are associated with the risk of myocardial infarction and high serum levels of IL18. Minor alleles of rs13015714 and rs917997 sites are associated with high risk of developing multifocal atherosclerosis and arterial hypertension in patients with stable coronary artery disease after myocardial infarction.
Conclusions: Thus, polymorphism in the genes of IL18 receptor is determine the IL18 contents and important in the development of coronary atherosclerosis, associated pathological conditions and the risk of acute coronary events; prospective monitoring of patients with early clinical signs of adverse events is required to confirm the role of IL18, IL18R1, and IL18RAP genes polymorphism in atherogenesis.
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| http://dx.doi.org/10.1080/08820139.2021.1876085 | DOI Listing |
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