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Objective: Patients requiring intrathecal baclofen (ITB) therapy are at high risk for surgical site infections (SSIs) given their poor functional status. After years of a nominal infection rate, there was an inexplicable increase in ITB pump infections at the authors' institution and multiple investigations offered no solution. Use of intraoperative topical antibiotics is well-documented in the orthopedic literature and was considered for ITB pump insertion.
View Article and Find Full Text PDFIntrathecal tobramycin and pausing induction chemotherapy for pediatric acute lymphoblastic leukemia facilitate successful management of disseminated Pseudomonas aeruginosa infection and meningitis.
Pediatr Blood Cancer
June 2021
Department of Pediatrics and Adolescent Medicine, Oulu University Hospital and PEDEGO Unit, University of Oulu, Oulu, Finland.
Pharmacokinetics of antibacterial agents in the CSF of children and adolescents.
Paediatr Drugs
April 2013
Department of Pharmacy, Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA.
The adequate management of central nervous system (CNS) infections requires that antimicrobial agents penetrate the blood-brain barrier (BBB) and achieve concentrations in the CNS adequate for eradication of the infecting pathogen. This review details the currently available literature on the pharmacokinetics (PK) of antibacterials in the CNS of children. Clinical trials affirm that the physicochemical properties of a drug remain one of the most important factors dictating penetration of antimicrobial agents into the CNS, irrespective of the population being treated (i.
View Article and Find Full Text PDFPharmacokinetic model for tobramycin in acinetobacter meningitis.
Ann Pharmacother
January 2002
Department of Pharmacy, La Fe University Hospital, 21 Campanar Av., 46009 Valencia, Spain.
Objective: To report a case of acinetobacter meningitis treated with a once-daily intravenous dose of tobramycin and to propose a pharmacokinetic model for the drug disposition.
Case Summary: A 28-year-old man with chronic hydrocephalus was admitted with a diagnosis of intracranial hypertension. Acinetobacter spp.
Clinical applications of a novel sustained-release injectable drug delivery system: DepoFoam technology.
Cancer J
December 2001
Department of Medicine and the Cancer Center, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
The therapeutic effectiveness of drugs is often limited by the inability to sustain therapeutic levels at the target site. Encapsulation of drugs in multivesicular lipid-based particles for sustained release is a novel approach to improving the pharmacokinetics of drug therapy. This paper reviews the preclinical and clinical literature on the applications and potential therapeutic benefits of DepoFoam technology, a novel sustained-release, injectable drug delivery system.
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