AI Article Synopsis
- - The study aimed to investigate the link between lithium use and the risk of respiratory infections in patients with bipolar disorder, given its known antiviral properties and low evidence in human studies.
- - Over a period from 2005 to 2013, researchers tracked over 51,000 individuals with bipolar disorder in Sweden, comparing the incidence of respiratory infections during periods when patients were treated with lithium versus when they were not.
- - Results showed a 28% lower rate of respiratory infections during lithium treatment, while valproate treatment was associated with a 35% increase in infection rates, suggesting lithium may have potential benefits beyond mood stabilization.
Article Abstract
Background: In vitro studies have demonstrated that lithium has antiviral properties, but evidence from human studies is scarce. Lithium is used as a mood stabilizer to treat patients with bipolar disorder. Here, the aim was to investigate the association between lithium use and the risk of respiratory infections in patients with bipolar disorder. To rule out the possibility that a potential association could be due to lithium's effect on psychiatric symptoms, we also studied the effect of valproate, which is an alternative to lithium used to prevent mood episodes in bipolar disorder.
Method: We followed 51,509 individuals diagnosed with bipolar disorder in the Swedish Patient register 2005-2013. We applied a within-individual design using stratified Cox regression to estimate the hazard ratios (HRs) of respiratory infections during treated periods compared with untreated periods.
Results: During follow-up, 5,760 respiratory infections were documented in the Swedish Patient Register. The incidence rate was 28% lower during lithium treatment (HR 0.73, 95% CI 0.61-0.86) and 35% higher during valproate treatment (HR 1.35, 95% CI 1.06-1.73) compared with periods off treatment.
Conclusions: This study provides real-world evidence that lithium is associated with decreased risk for respiratory infections and suggests that the repurposing potential of lithium for potential antiviral or antibacterial effects is worthy of investigation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847747 | PMC |
| http://dx.doi.org/10.1186/s40345-020-00208-y | DOI Listing |
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