Degenerative disease of the lumbar spine commonly develops with age and can cause debilitating pain or neurologic deficits. When minimally invasive treatments and pain management interventions fail to provide relief, the traditional treatment has consisted of decompression surgery followed by the possible need for lumbar fusion. A mechanical implant device, known as a Total Posterior Spine (TOPS) System, has been introduced as a potential dynamic alternative to fusion surgery following decompression. The device is a dynamic posterior arthroplasty via pedicle screw insertion that maintains mobility, flexibility, and range of motion by providing multiaxial, three-column stabilization. While currently approved for use in Europe, the device is undergoing clinical trials in the United States to determine efficacy and potential complications. This paper provides a comprehensive narrative review of this technique's mechanism, early clinical outcomes, and considerations for patient selection. A review of the literature identified both positive results and adverse effects. While TOPS' use shows excellent potential, additional prospective trials are needed to determine this system's long-term complications.
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http://dx.doi.org/10.7759/cureus.12361 | DOI Listing |
Toxics
December 2024
Department of Built Environment, North Carolina A&T State University, Greensboro, NC 27411, USA.
This study investigates the combined effects of environmental pollutants (lead, cadmium, total mercury) and behavioral factors (alcohol consumption, smoking) on depressive symptoms in women. Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 cycle, specifically exposure levels of heavy metals in blood samples, were used in this study. The analysis of these data included the application of descriptive statistics, linear regression, and Bayesian Kernel Machine Regression (BKMR) to explore associations between environmental exposures, behavioral factors, and depression.
View Article and Find Full Text PDFLife (Basel)
December 2024
Institute of Clinical and Experimental Therapeutics, Department of Physiology, Health Sciences University Center, University of Guadalajara, Guadalajara 44340, Jalisco, Mexico.
Proliferative diabetic retinopathy (PDR) is the most severe complication of chronic hyperglycaemi stimulates oxidative stress that changes the retinal basement membrane function and provokes neovascularization, macular edema and retinal detachment. But an oxidative-antioxidant biomarker assessment in ocular matrices, such as aqueous humor (AH) and vitreous, might show the oxidative stress (OS) status in the posterior segment. Here, we show a cross-sectional analytical study of 39 patients who had a vitrectomy and assess the levels of different oxidative-antioxidant biomarkers in blood, aqueous and vitreous humor in three groups: diabetes mellitus 2 (DM2) with PDR [DM(+)PDR(+)] ( =13), DM2 without PDR [DM(+)PDR(-)] ( = 13) and non-DM2 non-PDR [DM(-)PDR(-)] as the control group ( = 13).
View Article and Find Full Text PDFBioengineering (Basel)
November 2024
School of Medicine, Universidad de Concepción, Concepción 4030000, Chile.
The Modified Functional Reach Test (mFRT) was developed to assess sitting balance in individuals with spinal cord injury (SCI). No studies have explored which mFRT reach directions correlate with the center of pressure (CoP) variables in patients with motor-complete SCI (mcSCI). Addressing this gap is important for improving the clinical usefulness of the mFRT.
View Article and Find Full Text PDFDiagnostics (Basel)
December 2024
Departamento de Farmacología and CIBERehd, Facultad de Medicina, Universidad de Valencia, Av. Blasco Ibáñez, 15, 46010 Valencia, Spain.
: Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, primarily affects the gastrointestinal tract. Additionally, extraintestinal manifestations may occur in the liver, musculoskeletal system and eyes. Its etiology remains unknown, and further research is required in order to develop pharmacological drugs which achieve complete remission of the pathology.
View Article and Find Full Text PDFGenes (Basel)
November 2024
Swiss Federal Institute of Sport Magglingen SFISM, 2532 Magglingen, Switzerland.
Background: This study examines genetic variations in the systemic oxygen transport cascade during exhaustive exercise in physically trained tactical athletes. Research goal: To update the information on the distribution of influence of eleven polymorphisms in ten genes, namely ACE (rs1799752), AGT (rs699), MCT1 (rs1049434), HIF1A (rs11549465), COMT (rs4680), CKM (rs8111989), TNC (rs2104772), PTK2 (rs7460 and rs7843014), ACTN3 (rs1815739), and MSTN (rs1805086)-on the connected steps of oxygen transport during aerobic muscle work.
Methods: 251 young, healthy tactical athletes (including 12 females) with a systematic physical training history underwent exercise tests, including standardized endurance running with a 12.
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