Necrotic enteritis caused by has reemerged as a severe poultry disease worldwide since the ban on the routine use of antibiotics in animal feed. Probiotics are considered alternatives to antibiotic growth promoters. species are the most common microorganisms used as probiotics in the feed industry. The current study investigated the growth and surfactin levels of in solid-state fermentation using different substrates and evaluated the effects of -fermented products on growth performance and intestinal morphology in broilers exposed to . The highest viable biomass and surfactin concentration of -fermented products was observed at 2% molasses and 20% soybean meal supplementation during fermentation (<0.05). -fermented product-derived surfactin inhibited the growth of in a dose dependent manner (<0.05). -fermented product supplementation (2 g/kg) significantly improved the body weight and average daily gain weight of broilers challenged with (<0.05). -fermented products significantly alleviated necrotic lesions and ameliorated intestinal morphology in broilers exposed to (<0.05). Collectively, these observations demonstrate that -fermented products improve growth performance and gut morphology in broilers under challenge. -fermented products may have the potential to be used as alternatives to antibiotic growth promoters for preventive treatments against in broilers.
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http://dx.doi.org/10.2141/jpsa.0200010 | DOI Listing |
J Gastroenterol Hepatol
January 2025
Faculty of Medicine, Division of Gastroenterology, Department of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Background: Gas production due to fermentation from fructose malabsorption (FM) or lactose malabsorption (LM) and small intestinal bacterial overgrowth (SIBO) contribute to the development of gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). However, the impact of the carbohydrate malabsorption, unlike SIBO, is relatively unknown.
Methodology: A multicenter, prospective study of consecutive adults with IBS who underwent a hydrogen breath test (HBT) (glucose, 75 g; lactose, 25 g; or fructose, 25 g) was conducted.
Chem Biodivers
January 2025
Nanjing Forestry University, Department of Food Science and Technology, Longpan Road 159, Nanjing, CHINA.
Ginkgo biloba (G. biloba) exocarp, a by-product of seed production, is produced in an amount of over 75,000 tons annually in China. However, due to the lack of suitable processing methods, it is predominantly discarded as agricultural waste, resulting in substantial waste of resource.
View Article and Find Full Text PDFBioresour Bioprocess
January 2025
Biotechnology Processes Unit, IMDEA Energy, Avda. Ramón de la Sagra 3, Móstoles, Madrid, 28935, Spain.
This research investigated the acidogenic fermentation (AF) of sugar cane molasses in an up-flow anaerobic sludge blanket (UASB) reactor for the production of carboxylates. The first step was to assess the optimum process temperature (25, 35 or 55 ºC) using two different granular inocula, one from a brewery company (BGS) and other from a paper plant company (PGS). These experiments determined that the most suitable temperature for carboxylates production was 25 ºC, obtaining higher bioconversions (27.
View Article and Find Full Text PDFAm J Physiol Cell Physiol
January 2025
Interdisciplinary Department of Medicine, University of Bari Aldo Moro School of Medicine, Piazza G. Cesare, 11 - 70124 Bari, Italy.
Resistance to drugs is one of the major issues affecting the response to pharmacological treatments for tumors. Different mechanisms have been proposed to explain the development of cancer drug resistance (CDR), and several approaches to overcome it have been suggested. However, the biological basis of CDR remains unclear.
View Article and Find Full Text PDFPrep Biochem Biotechnol
January 2025
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
L-asparaginase (asparagine amidohydrolase) contributes to 40% of the total enzyme demands worldwide and is one-third of the global requirement as an anti-cancerous drug in treating acute lymphocytic leukemia (ALL), a type of leukemia. This protein breaks down L-asparagine into aspartic acid and ammonia those involved in ALL, rely on for growth and survival. Both non-recombinant and recombinant L-asparaginase can be produced by bacteria when a suitable substrate and method (solid-state fermentation (SSF) or submerged fermentation (SmF) which are techniques to grow microorganisms under controlled conditions), is provided.
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