According to the pharmacophore binding strategy and principle of bioelectronic isobaric, used the sulfonylurea bridge as the parent structure, a series of novel thiourea compounds containing aromatic-substituted pyrimidines were designed and synthesized. The preliminary herbicidal activity tests showed that some compounds had good herbicidal activity against Digitaria adscendens, Amaranthus retroflexus, especially for compound 4d and 4f. The results showed that compound 4d had an inhibition rate of 81.5% on the root growth of Brassica napus L. at the concentration of 100 mg L, and compound 4f had an inhibition rate of 81% on the root growth of Digitaria adscendens at the concentration of 100 mg L. Compounds 4d and 4f had higher comparative activity on Echinochloa crus-galli than the commercial herbicide bensulfuron-methyl. The preliminary structure-activity relationship (SAR) was also summarized. We also tested the in vivo AHAS enzyme activity inhibition experiment of 14 compounds at 100 mg L, and the results showed that they all have inhibitory activity on the enzyme, with the highest inhibition rate reaching 44.4% (compound 4d). Based on the results of molecular docking to yeast acetohydroxyacid synthase (AHAS), the possible herbicidal activity mechanism of these compounds was evaluated.
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http://dx.doi.org/10.1016/j.pestbp.2020.104766 | DOI Listing |
Chemosphere
December 2024
Inorganic Materials Research Laboratory, Department of Chemistry, Trent University, 1600 West Bank Dr., Peterborough, ON, Canada K9J 7B8. Electronic address:
2,4-dichlorophenoxy acetic acid (2,4-D) and 1,1-dimethyl-4,4-bipiridinium chloride (paraquat) are among the most widely used herbicides and are known to be toxic. Fabrication of green adsorbents which are capable of removing both herbicides remains a challenge. Here, we fabricate a novel adsorbent from tropical waste wood and use a facile, chitosan-mediated N-heteroatom functionalization technique to augment surface nitrogen and improve specific surface area.
View Article and Find Full Text PDFEnviron Sci Pollut Res Int
December 2024
Laboratório de Ecologia e Conservação, Universidade Federal da Fronteira Sul, Campus Erechim, RS 135 - km 72, nº 200, Erechim, RS, Brazil.
Atrazine and glyphosate are considered some of the main pollutants for aquatic ecosystems, directly and indirectly affecting non-target organisms, such as amphibians. This study aimed to evaluate the sublethal effects of different concentrations of atrazine-based herbicide (ABH) and glyphosate-based herbicide (GBH) commercial formulations, both individually and in a mixture, through toxicity tests on the larval stage of Boana faber. Tadpoles were exposed to concentrations of ABH (2, 9.
View Article and Find Full Text PDFJ Hazard Mater
December 2024
College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang 150040, PR China. Electronic address:
Acetochlor is a widely used and highly effective herbicide. Its overuse poses significant threats to biosecurity and ecological integrity, particularly affecting free-ranging birds. Data on its impact, especially mechanisms of liver toxicity in chickens, are lacking.
View Article and Find Full Text PDFJ Agric Food Chem
December 2024
College of Science, Hebei Agricultural University, Baoding 071001, P. R. China.
Transketolase (TKL; EC 2.2.1.
View Article and Find Full Text PDFSci Total Environ
December 2024
Key Laboratory of Integrated Rice-Fish Farming Ecosystem, Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Key Laboratory of Freshwater Aquatic Genetic Resources, Ministry of Agriculture and Rural Affairs, Shanghai Ocean University, Shanghai 201306, China; Shanghai Aquaculture Engineering and Technology Research Centre, Shanghai Ocean University, Shanghai 201306, China; National Demonstration Center for Experimental Fisheries Science Education, Shanghai Ocean University, Shanghai 201306, China.
Glyphosate (Gly), the world's most widely used herbicide in agriculture, can poison the red swamp crayfish, Procambarus clarkii, via spray drift and surface runoff into surface waters. However, there is a paucity of research on the mechanisms that affect crayfish tolerance to Gly at typical environmental concentrations. To address this research gap, we investigated the effects of Gly stress (0, 6, 12, 24, and 72 h) at different concentrations (0, 1.
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