Introduction: Inadequate treatment response and emotional blunting are common challenges with selective serotonin reuptake inhibitors/serotonin-noradrenaline reuptake inhibitors (SSRIs/SNRIs) for major depressive disorder (MDD). We investigated the effectiveness of vortioxetine on emotional blunting in patients with partial response to treatment with SSRIs/SNRIs.
Methods: Patients with MDD who experienced a partial response to SSRI/SNRI monotherapy at adequate dose for ≥6 weeks were switched to 8 weeks of vortioxetine treatment 10-20 mg/day (Study NCT03835715). Key inclusion criteria were Montgomery-Åsberg Depression Rating Scale (MADRS) total score >21 and <29, current major depressive episode <12 months, Oxford Depression Questionnaire (ODQ) total score ≥50, and confirmation of emotional blunting by standardized screening question. Emotional blunting was assessed by ODQ and depressive symptoms by MADRS. Other outcomes assessed included motivation and energy (Motivation and Energy Inventory [MEI]), cognitive performance (Digit Symbol Substitution Test [DSST]), and overall functioning (Sheehan Disability Scale [SDS]).
Results: At week 8, patients (N=143) had improved by -29.8 points (p<0.0001) in ODQ total score; 50% reported no emotional blunting in response to standardized screening question. Significant improvements were observed on the DSST, MEI, and SDS at all time points assessed, and 47% of patients were in remission (MADRS total score ≤10) at week 8. The most common treatment-emergent adverse events included nausea, headache, dizziness, vomiting, and diarrhea.
Limitations: No prospective phase before medication switch.
Conclusion: Vortioxetine 10-20 mg effectively improved emotional blunting, overall functioning, motivation and energy, cognitive performance, and depressive symptoms in patients with MDD with partial response to SSRI/SNRI therapy and emotional blunting.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jad.2020.11.106 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Neuroimaging findings of adolescent depression: A review by the Research Domain Criteria (RDoC) framework.
Psychiatry Res Neuroimaging
December 2024
Department of Psychiatry, University of Nebraska Medical Center, 42nd and Emile, Omaha, 68198, NE, United States of America. Electronic address:
This review examines neuroimaging studies on adolescent depression (AD) within the Research Domain Criteria (RDoC) framework, focusing on fMRI, DTI, and EEG findings. The research highlights disrupted connectivity in several neural networks-such as the affective, reward processing, cognitive control, and default mode networks-that underpin emotional and cognitive dysfunctions in AD. Notably, hypoconnectivity in the affective and cognitive control networks correlates with deficits in emotional processing and executive functioning, while hyperactivity in the default mode network relates to excessive self-referential thoughts.
View Article and Find Full Text PDFPsychotic disorders in HIV-positive versus HIV-negative patients: comparative study of clinical characteristics.
BJPsych Open
December 2024
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Background: Clinical characteristics of psychosis in HIV infection have been described, but there have been limited comparative studies in HIV-endemic low-resource regions.
Aim: To compare clinical characteristics of psychosis in HIV-positive and HIV-negative patients at the main psychiatric referral units in Uganda.
Method: Patients with psychosis were consecutively recruited and completed a standardised demographic questionnaire and psychiatric and laboratory assessments including an HIV test.
Introduction: Individuals with borderline personality disorder (BPD) are thought to experience specific biosocial vulnerabilities that give rise to a maladaptive negativity bias in the perception and expression of emotions. However, while this negative bias has been identified in adults with full threshold BPD or high BPD features, it is unclear whether it is evident earlier in the course of the disorder-that being, young persons with first presentation BPD meeting three or more BPD features, as defined by early intervention models.
Methods: The current study compared patterns of facial responding in individuals aged 15-25 first presenting to a specialist outpatient service with three or more BPD features (n = 32) to age-matched healthy controls (n = 46).
Neural Reactivity to Social Reward Moderates the Association Between Social Media Use and Momentary Positive Affect in Adolescents.
Affect Sci
December 2024
Department of Psychology and Human Development, Vanderbilt University, Nashville, TN USA.
Article Synopsis
- Peer relationships are crucial in adolescence, and this study explores how social media use impacts teens' emotional health, focusing on brain function differences.
- It involved 145 adolescents aged 14-17, assessing social media use and emotional responses through ecological momentary assessment and tasks designed to gauge brain activity related to rewards.
- Findings showed that social media use correlated with lower positive emotion, particularly in those with less brain responsiveness to social rewards, with the effect being more pronounced in females.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!