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Inflammatory aortic aneurysm a rare presentation of abdominal aortic aneurysm (AAA): A case report study.
Int J Surg Case Rep
January 2025
Anesthesiology Research Center, Department of Anesthesiology, Alzahra Hospital, Guilan University of Medical Sciences, Rasht, Iran.
Introduction: An Inflammatory abdominal aortic aneurysm (IAAA) is an inflammatory condition involving the abdominal aorta, accounting for 4-7 % of all abdominal aortic aneurysms (AAAs). In general, AAA is asymptomatic, but IAAA can have some features, including pain, constitutional symptoms, elevated inflammatory markers, and distinguishes findings on imaging.
Presentation Of Case: This article is about a 65-year-old man with flank pain who was diagnosed incidentally with IAAA and underwent surgery.
Screen for temperature-sensitive mutants of non-essential yeast genes.
Methods Enzymol
November 2024
Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS Centre for Integrative Biological Signalling Studies, University of Freiburg, Freiburg, Germany; BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany. Electronic address:
Yeast deletion mutants of crucial genes are often associated with a number of secondary defects, which hamper the analysis of primary protein function. Therefore, temperature-sensitive mutants are valuable tools to evaluate protein function in a focused and often reversible manner. However, temperature-sensitive mutants are uncommon for non-essential genes that nevertheless may have strong defects.
View Article and Find Full Text PDFAbdominal aortic aneurysm repair in Sweden vs. Finland: benefits of population-wide screening.
Eur Heart J
November 2024
Department of Vascular Surgery, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 2, FI-00290 Helsinki, Finland.
Background And Aims: In 2006, screening of 65-year-old men for abdominal aortic aneurysm (AAA) was started in Sweden. Decline in aneurysm-related mortality has been reported since, but aneurysm incidence has been diminishing globally. Neighbouring Finland with similar population structure and health care system has no AAA screening programme.
View Article and Find Full Text PDFMitochondrial transporters facilitate the exchange of diverse metabolic intermediates across the inner mitochondrial membrane, ensuring an adequate supply of substrates and cofactors to support redox and biosynthetic reactions within the mitochondrial matrix. However, the regulatory mechanisms governing the abundance of these transporters, crucial for maintaining metabolic compartmentalization and mitochondrial functions, remain poorly defined. Through analysis of protein half-life data and mRNA-protein correlations, we identified SLC25A38, a mitochondrial glycine transporter, as a short- lived protein with a half-life of 4 hours under steady-state conditions.
View Article and Find Full Text PDFProhibitins, Phb1 and Phb2, function as Atg8 receptors to support yeast mitophagy and also play a negative regulatory role in Atg32 processing.
Autophagy
November 2024
Departamento de Bioquímica y Biología Estructural, Instituto de Fisiología Celular, Mexico City, México.
The prohibitins Phb1 and Phb2 assemble at the mitochondrial inner membrane to form a multi-dimeric complex. These scaffold proteins are highly conserved in eukaryotic cells, from yeast to mammals, and have been implicated in a variety of mitochondrial functions including aging, proliferation, and degenerative and metabolic diseases. In mammals, PHB2 regulates PINK1-PRKN mediated mitophagy by interacting with lipidated MAP1LC3B/LC3B.
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