AI Article Synopsis
- * The analysis included 42 studies with over 4,200 participants and found that patients on antipsychotic medication had higher levels of KYN compared to controls.
- * Higher KYN levels in cerebrospinal fluid (CSF) and specific changes in metabolites were noted in SCZ patients, suggesting the KYN pathway may play a role in the development of schizophrenia and its treatment.
Article Abstract
The kynurenine (KYN) pathway is postulated to play various roles in immune system dysregulation of schizophrenia (SCZ). We conducted a meta-analysis to explore the association between six key metabolites of KYN pathway (i.e., tryptophan (TRP), KYN, quinolinic acid (QUIN), and kynurenic acid (KYNA)) and SCZ. Priori Bonferroni adjustments were conducted for multiple comparisons. In total, 42 studies that examined the relationship between the metabolites in KYN pathway mentioned above and SCZ in 4217 participants and nine studies that examined alterations of these metabolites after antipsychotic treatments were included. The results demonstrate that (1) subjects with prescribed medication had significantly higher KYN levels when compared to controls; (2) higher KYN levels in cerebrospinal fluid (CSF), lower plasma KYN levels and higher CSF KYNA levels were associated with SCZ; (3) the KYN levels were higher in subjects with SCZ after antipsychotic treatments when compared with baseline. The evidence provides valuable insight of the potential underlying involvement of the KYN pathway in the pathogenesis of SCZ.
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| http://dx.doi.org/10.1016/j.neubiorev.2021.01.018 | DOI Listing |
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