Two new biflavanones ( and ), three new bichalconoids (-), and 11 known flavonoid analogues (-) were isolated from the stem bark extract (CHOH-CHCl, 7:3, v/v) of . The structures of the isolated metabolites were elucidated by NMR spectroscopic and mass spectrometric analyses. The crude extract and the isolated metabolites were evaluated for antibacterial activity against (Gram-positive) and (Gram-negative) as well as for cytotoxicity against the MCF-7 human breast cancer cell line. The crude extract and holstiinone A () exhibited moderate antibacterial activity against with MIC values of 9.1 μg/mL and 14 μM, respectively. The crude extract and lophirone F () showed cytotoxicity against MCF-7 with EC values of 11 μg/mL and 24 μM, respectively. The other isolated metabolites showed no significant antibacterial activities (MIC > 250 μM) and cytotoxicities (EC ≥ 350 μM).
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| http://dx.doi.org/10.1021/acs.jnatprod.0c01017 | DOI Listing |
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