Background: Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia (NICTH). As NICTH is a rare lesion, the natural course of NICTH is not well understood. We report a case of NICTH that was observed 30 years before the onset of hypoglycemia.
Case Summary: A 50-year-old man was diagnosed with an abnormal right chest shadow during a routine X-ray examination, but no further examination was undertaken because the lesion appeared benign. Thirty years after the tumor discovery, the patient was admitted to the hospital with symptoms of severe hypoglycemia, which was diagnosed as NICTH based on a complete examination. The tumor was resected and found to be a solitary fibrous mass (15.6 cm × 13.7 cm × 10.4 cm); thereafter, the patient's blood glucose levels normalized and he completely recovered.
Conclusion: NICTH can have an acute onset, even if the tumor has been present and asymptomatic over a long time period.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7809661 | PMC |
| http://dx.doi.org/10.12998/wjcc.v9.i1.163 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Non-islet cell tumor hypoglycemia (NICTH) is a paraneoplastic syndrome associated with non-mesenchymal-derived and epithelial tumors. A 37-year-old male with stage IVB hepatocellular carcinoma (HCC) and pulmonary metastases presented with recurrent hypoglycemia despite glucose supplementation. Laboratory findings revealed low insulin growth factor 1 (IGF-1) (15 ng/mL), elevated insulin growth factor 2 (IGF-2) (395 ng/ml), and an IGF-2:IGF-1 ratio of 26:1, consistent with NICTH.
View Article and Find Full Text PDFPotential Utility of Circulating MicroRNA-483 as a Biomarker for IGF-II-Associated Non-Islet Cell Tumor Hypoglycemia.
J Clin Endocrinol Metab
December 2024
Department of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, Tokyo, Japan.
Context: In most cases of non-islet cell tumor hypoglycemia (NICTH), high molecular weight forms of insulin-like growth factor II, commonly referred to as big IGF-II, cause hypoglycemia. MicroRNA-483 (miR-483), encoded within an intron of IGF2 gene, has been suggested to be co-expressed with IGF-II.
Objective: The aim of this study is to demonstrate the utility and reliability of circulating miR-483 as a biomarker for diagnosis and therapeutic outcome of NICTH.
A Paradigm Shift in Renal Cell Carcinoma: Recognizing Hypoglycaemia as a Significant Paraneoplastic Syndrome.
Cureus
November 2024
Department of General Medicine, Sri Ramaswamy Memorial (SRM) Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND.
Recurrent hypoglycaemia is a rare paraneoplastic syndrome associated with several cancers, including renal cell carcinoma (RCC). Here we present a curious case of a patient with type 2 diabetes mellitus (T2DM) who had numerous hospitalisations due to recurrent hypoglycaemia. A well-defined lesion at the lower pole of the right kidney and bilateral pyelonephritis were found during imaging investigations.
View Article and Find Full Text PDFStructure, interaction and nervous connectivity of beta cell primary cilia.
Nat Commun
October 2024
Molecular Diabetology, University Hospital and Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany.
Article Synopsis
- - Primary cilia in pancreatic beta cells are crucial for paracrine signaling, and their dysfunction is linked to diabetes, but their structural functions are not well understood.
- - Researchers used electron and expansion microscopy to create 3D models of these cilia, revealing they are confined in deep pockets, lack movement components, and have an unstructured organization.
- - The study identified unique interactions between beta cell cilia and other cells, including specialized connections to cholinergic nerves, emphasizing the importance of cilia in integrating signals that affect islet function in relation to health and diabetes.
Clinical characteristics of gastrointestinal stromal tumors with hypoglycemia.
Oncol Lett
December 2024
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.
Article Synopsis
- * This study specifically looked at the under-researched issue of hypoglycemia in GIST patients, identifying symptoms, causes, and its overall prevalence of 4.1%.
- * A detailed analysis revealed poor prognosis in recurrent hypoglycemic cases and highlighted a specific instance related to non-islet cell tumor hypoglycemia (NICTH), which showed unique histological features and insulin-like growth factor II amplification, indicating a need for further research.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!