This report presents the longest spanning intradural myxopapillary ependymoma consisting of 23 vertebral segments in the literature. An 11-year-old boy presented with right arm pain, mid back pain and progressive paraparesis associated with urinary retention. On MRI, the patient was found to have an intradural lesion extending from C5 to S3. The patient underwent T7 and T8 laminectomies with an almost total resection except for a minimal residual adhering to the spinal cord. The patient with the largest spanning spinal cord ependymoma was managed satisfactorily without significant morbidity. A small laminectomy may be used in some occasions despite the tumour's extensive size because it may have a single point of attachment to the cord.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7845678PMC
http://dx.doi.org/10.1136/bcr-2020-239453DOI Listing

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Myxopapillary ependymoma (MPE) is a rare, slow-growing tumor that commonly arises in the lumbosacral region of the spinal cord, within the filum terminale and cauda equina. The frequent presentation of MPE is back, sacral, or leg pain. The tumor's size, site, and extension usually influence these symptoms.

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The many faces of myxopapillary ependynomas.

AJNR Am J Neuroradiol

September 2024

From the Department of Radiology, Geneva University Hospitals, Geneva, Switzerland (I.H.), Department of Neuropathology, Geneva University Hospitals, Geneva, Switzerland (K.L.E., D.M), Clinic of Granjettes, Hirslanden, Chêne-Bougeries, Swizerland (M.I.V.) and Geneva University, Faculty of Medicine, Geneva Swizerland (I. H. and M.I.V.).

Article Synopsis
  • Myxopapillary ependymomas (MPE) are rare, grade 2 spinal tumors known for their slow growth and benign nature but have a high recurrence risk and can spread through cerebrospinal fluid.* -
  • This study analyzed MRI characteristics and histopathological patterns in 13 patients with MPE, focusing on tumor location, size, signal intensity, and enhancement features.* -
  • Findings revealed typical MRI features such as T2 hyperintensity and contrast enhancement, with larger tumors often showing a microcystic pattern, while smaller tumors were usually solid, indicating a possible connection between tumor characteristics and histopathological patterns.*
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Background: Ependymomas, rare glial brain tumors, account for <5% of all brain tumors. Interestingly, over 60% of ependymomas occur in the spinal cord of adults, including those originating from the filum terminale, while the rest are found within the brain. The World Health Organization (WHO) categorizes ependymomas into three grades: subependymomas and myxopapillary ependymomas ([MEPNs]; WHO grade I), classic ependymomas (WHO grade II), and anaplastic ependymomas (WHO grade III).

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Myxopapillary ependymomas (MPEs) are well-circumscribed tumors arising mainly from the caudal neuraxis, i.e., conus medullaris (CM) and filum terminale (FT), commonly seen in adults with median age at presentation of 39 years.

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