Immunotactoid glomerulopathy (ITG) is a rare disease diagnosed by kidney biopsy showing characteristic microtubules, often in parallel arrays, in glomeruli on electron microscopy. Most cases are caused by lymphoproliferative disorders that produce monoclonal immunoglobulins that cause kidney damage, but these disorders do not meet criteria for overt malignancy. The published literature on ITG is limited. In this issue of Kidney International, 2 manuscripts provide significant insight into the clinical presentation, pathology, and treatment of ITG.
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Ultrastructural overlap between immunotactoid and cryoglobulin glomerulopathy: A case report.
Nephrology (Carlton)
January 2025
Department of Nephrology, Royal North Shore Hospital, St Leonards, New South Wales, Australia.
Immunotactoid glomerulopathy (ITG), a condition characterised by highly organised microtubules on electron microscopy, and cryoglobulin glomerulopathy (CG) are rare forms of kidney injury that may be encountered in patients with cryoglobulinaemia. It has been proposed these two entities are part of the same disease process following observed clinical and histological similarities.
View Article and Find Full Text PDFSuccessful Treatment of Monoclonal Immunotactoid Glomerulopathy Associated with Chronic Lymphocytic Leukemia Using Ibrutinib.
Intern Med
October 2024
Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Japan.
Article Synopsis
- * mITG is a rare kidney disease that involves abnormal immune deposits and is often linked to blood disorders like leukemia.
- * The patient was treated with ibrutinib, a medication that targets Bruton tyrosine kinase, leading to complete renal remission after 24 months, marking a novel approach as there are no prior reports of using ibrutinib for mITG treatment.
Leukocytoclastic vasculitis as a presenting symptom of immunotactoid glomerulopathy.
Nephrology (Carlton)
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Division of Nephrology, Department of Medicine, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand.
Immunotactoid Glomerulopathy Masquerading as Heart Failure.
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Nephrology, University of Florida College of Medicine, Jacksonville, USA.
Immunotactoid glomerulopathy (ITG) is a rare form of glomerular disease. It is characterized by organized, dense immunoglobulin deposits in the glomerulus, impairing glomerular function and filtration. The prognosis tends to be poor, and the majority of patients develop end-stage renal disease (ESRD).
View Article and Find Full Text PDFParaprotein-Mediated Glomerular Diseases.
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Department of Medicine, Section of Nephrology, University of Chicago, Chicago, IL. Electronic address:
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- * Kidney biopsies are essential in diagnosing these conditions, as they reveal specific histological patterns categorized into organized and nonorganized deposits based on immunofluorescence and electron microscopy findings.
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