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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027512PMC
http://dx.doi.org/10.1007/s10875-021-00976-xDOI Listing

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Long-term immunological changes after corrective cardiac surgery.

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December 2024

Department of Pediatrics, Institute of Health Sciences, Division of Pediatric Immunology and Allergy and Master's/Doctoral Program, Jeffrey Modell Primary Immunodeficiency Diagnosis Center, Işıl Barlan Translational Medicine Center, Immunodeficiency Application and Research Center, Faculty of Medicine, Marmara University, Istanbul, Turkey.

Article Synopsis
  • * A study involving 22 patients post-thymectomy indicated significant long-term immunological changes, such as lymphopenia, reduced naive T cell counts, and low immunoglobulin levels, pointing to early immune aging.
  • * Despite these changes, most patients still showed positive vaccine responses, but the findings suggest a need for preserving thymic tissue during surgery and increased monitoring for immune-related complications over time.
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[Newborn screening for severe combined immunodeficiencies (SCID) in Germany].

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Pädiatrische Hämatologie und Onkologie, Zentrum für Kinder- und Jugendmedizin und Centrum für Chronische Immundefizienz, Institut für Immundefizienz, Medizinische Fakultät, Universitätsklinikum Freiburg, Freiburg, Deutschland.

Patients with a severe combined immunodeficiency (SCID) harbor genetic mutations disrupting T cell immunity and hence suffer severe, life-threatening infections or manifestations of immune dysregulation within the first months of their life. The only cure is to correct their immune system, usually by means of hematopoietic stem cell transplantation (HSCT). Pilot studies and national programs in the United States and in European countries have shown that patients can be identified at an early asymptomatic stage through newborn screening.

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