Among the non-pharmacological methods under development for maintaining cognitive function across the lifespan is computerized cognitive training (CCT). There has been considerable interest in using CCT to slow or remediate age-related cognitive decline, both normal and pathological. Toward these ends, it would be useful to know how the effects of CCT on cognitive function vary over the course of normal cognitive aging. Are there changes in either 1) the overall efficacy of CCT or 2) which cognitive faculties are affected? To address these two questions, we reanalyzed results from a large online study by Hardy et al. (1) of 4,715 adults between 18 and 80 that examined effects of CCT on both a neuropsychological test battery and self-reported ratings of cognition and affect in daily living. Combined across all participants, Hardy et al. found greater improvement on both types of assessment following 10 weeks of CCT with the commercial program Lumosity, as compared to practice with a control activity involving computerized crossword puzzles. The present study compared the size of these effects on the older (50-80) and younger (18-49) participants. To address the question of overall efficacy, we examined CCT effects (treatment minus control) on overall performance of the test battery and mean rating. No significant difference on either measure was found between the two age cohorts. To address the question of whether the same magnitude of overall effects on both age cohorts was due to equivalent effects on the same set of underlying cognitive functions, we examined the patterns of CCT effects across individual subtests and rated items. These patterns did not differ significantly between the two age cohorts. Our findings suggest that benefits from CCT can occur to a similar degree and in a similar way across an extended part of the adult lifespan. Moreover, the overall effects of CCT delivered over the internet were of the same small to medium size as those typically found in the lab or clinic. Besides improving access and reducing the cost of CCT for older adults, delivery over the internet makes long-term training more practicable, which could potentially yield larger benefits.
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http://dx.doi.org/10.3389/fneur.2020.564317 | DOI Listing |
BMC Ophthalmol
January 2025
Department of Ophthalmology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, 233004, China.
Objectives: To evaluate the effects of short-acting cycloplegic agents, tropicamide and compound tropicamide, on ocular biological parameters and choroid thickness.
Methods: In this study, seventy pediatric subjects aged 6 to 13 years were randomly assigned to two groups: the tropicamide group and compound tropicamide group. Ocular biological parameters and choroidal thickness (CT) and subfoveal choroid thickness (SFCT) were measured in both groups and were retested 40 min after drug administration.
Environ Toxicol Chem
January 2025
Laboratorio de Ecotoxicología, Facultad de Humanidades y Ciencias, Universidad Nacional del Litoral (UNL), Santa Fe, Argentina.
The combination of silver nanoparticles (AgNPs) and ciprofloxacin (CIP) can be considered an alternative to combat multidrug-resistant microbial infections. However, knowledge about their combined toxicity is scarce after being released in an aquatic environment. The present study evaluated the individual toxicity of AgNPs and CIP and their combined toxicity on the unicellular green microalga Chlorella vulgaris, evaluating cellular responses and conducting metabolomic analysis.
View Article and Find Full Text PDFClin EEG Neurosci
January 2025
Division of Physiology and Neuroscience, Department of Functional Sciences, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Complex childhood trauma (CCT) involves prolonged exposure to severe interpersonal stressors, leading to deficits in executive functioning and self-regulation during adolescence, a critical period for neurodevelopment. While qEEG parameters, particularly alpha oscillations, have been proposed as potential biomarkers for trauma, empirical documentation in developmental samples is limited. .
View Article and Find Full Text PDFCornea
January 2025
Department of Ophthalmology, Rothschild Foundation, Paris, France; and.
Purpose: The purpose of this study was to investigate the effect of hypoxia and hypobaric conditions on refraction and central corneal thickness on healthy corneas during an ascent without oxygen supplementation above 7000 m (23 000 ft).
Methods: Twelve multinational mountaineers were included in a prospective observational cohort study during an expedition to the Korzhenevskoi Peak (7105 m). The two patients excluded from the study had a history with keratoconus or were current wearers of rigid contact lenses.
Ophthalmic Physiol Opt
January 2025
Department of Ophthalmology and Visual Science, Tzu Chi University, Hualien, Taiwan.
Purpose: This study evaluated the effects of orthokeratology and 0.01% atropine on corneal biomechanical properties (CBPs) and myopia progression in children, focusing on their association with axial length (AL) changes and treatment outcomes.
Methods: In this 1-year prospective study, 53 children (aged 8-17 years) were enrolled, with 30 undergoing orthokeratology and 23 receiving 0.
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