The energy levels of hydrogen-like atomic systems can be calculated with great precision. Starting from their quantum mechanical solution, they have been refined over the years to include the electron spin, the relativistic and quantum field effects, and tiny energy shifts related to the complex structure of the nucleus. These energy shifts caused by the nuclear structure are vastly magnified in hydrogen-like systems formed by a negative muon and a nucleus, so spectroscopy of these muonic ions can be used to investigate the nuclear structure with high precision. Here we present the measurement of two 2S-2P transitions in the muonic helium-4 ion that yields a precise determination of the root-mean-square charge radius of the α particle of 1.67824(83) femtometres. This determination from atomic spectroscopy is in excellent agreement with the value from electron scattering, but a factor of 4.8 more precise, providing a benchmark for few-nucleon theories, lattice quantum chromodynamics and electron scattering. This agreement also constrains several beyond-standard-model theories proposed to explain the proton-radius puzzle, in line with recent determinations of the proton charge radius, and establishes spectroscopy of light muonic atoms and ions as a precise tool for studies of nuclear properties.
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http://dx.doi.org/10.1038/s41586-021-03183-1 | DOI Listing |
J Cell Biochem
January 2025
Bioinformatics Division I Microbiology Division, ICMR-Regional Medical Research Centre, Bhubaneswar, Odisha, India.
B0AT1 (SLC6A19) is a major sodium-coupled neutral amino acid transporter that relies on angiotensin converting enzyme 2 (ACE2) or collectrin for membrane trafficking. Despite its significant role in disorders associated with amino acid metabolism, there is a deficit of comprehensive structure-function understanding of B0AT1 in lipid environment. Herein, we have employed molecular dynamics (MD) simulations to explore the architectural characteristics of B0AT1 in two distinct environments: a simplified POPC bilayer and a complex lipid system replicating the native membrane composition.
View Article and Find Full Text PDFNat Commun
January 2025
Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai, 201204, China.
Compared with widely established monovalent-ion batteries, aqueous multivalent-ion batteries promise higher capacity release by achieving multiple electron-transfer events per ion intercalation in the host material. Despite plausibility, this high-capacity dream is untenable with the total tolerable redox charge-transfer limit of the host material for all carrier species equally, which is historically assumed to depend on the material rather than the guest carrier itself, and the kinetic hysteresis induced by larger charge/radius ratios induced kinetic hysteresis further enlarges the divide. Herein, we report that copper carrier redox in vanadium sulfide (VS) exceeds the intrinsic intercalation capacity boundary, with the highest capacity release as 675 mAh g at 0.
View Article and Find Full Text PDFAdv Colloid Interface Sci
December 2024
Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, PL-30239 Krakow, Poland. Electronic address:
Chitosan, a biocompatible polysaccharide, finds a wide range of applications, inter alia as an antimicrobial agent, stabilizer of food products, cosmetics, and in the targeted delivery of drugs and stem cells. This work represents a comprehensive review of the properties of chitosan molecule and its aqueous solutions uniquely combining theoretical modeling and experimental results. The emphasis is on physicochemical aspects which were sparsely considered in previous reviews.
View Article and Find Full Text PDFJ Colloid Interface Sci
December 2024
Department of Chemical and Biomolecular Engineering, Case School of Engineering, Case Western Reserve University, Cleveland, OH 44106, United States.
We present a study combining experimental measurements, theoretical analysis, and simulations to investigate core-shell microcapsules interacting with a solid boundary, with a particular focus on understanding the short-range potential energy well arising from the tethered force. The microcapsules, fabricated using a Pickering emulsion template with a cinnamon oil core and calcium alginate shell, were characterized for size (∼5-6μm in diameter) and surface charge (∼-20mV). We employed total internal reflection microscopy and particle tracking to measure the microcapsule-boundary interactions and diffusion, from which potential energy and diffusivity profiles were derived.
View Article and Find Full Text PDFBiochemistry
December 2024
Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
The effects of guanidinium hydrochloride (GdmCl) on two intrinsically disordered proteins (IDPs) are investigated using simulations of the self-organized polymer-IDP (SOP-IDP) model. The impact of GdmCl is taken into account using the molecular transfer model (MTM). We show that due to the dramatic reduction in the stiffness of the highly charged Prothymosin-α (ProTα) with increasing concentration of GdmCl ([GdmCl]), the radius of gyration () decreases sharply until about 1.
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