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Afadin Sorts Different Retinal Neuron Types into Accurate Cellular Layers.
bioRxiv
December 2024
Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94158, USA.
Neurons use cell-adhesion molecules (CAMs) to interact with other neurons and the extracellular environment: the combination of CAMs specifies migration patterns, neuronal morphologies, and synaptic connections across diverse neuron types. Yet little is known regarding the intracellular signaling cascade mediating the CAM recognitions at the cell surface across different neuron types. In this study, we investigated the neural developmental role of Afadin, a cytosolic adapter protein that connects multiple CAM families to intracellular F-actin.
View Article and Find Full Text PDFDietary copper improves intestinal structural integrity in juvenile grass carp () probably related to its increased intestinal antioxidant capacity and apical junction complex.
Anim Nutr
September 2024
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, 611130, China.
This research evaluated the effects of copper (Cu) on intestinal antioxidant capacity and apical junctional complex (AJC) in juvenile grass carp. A total of 1080 healthy juvenile grass carp (11.16 ± 0.
View Article and Find Full Text PDFSpatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.
Adv Sci (Weinh)
December 2023
VIB-KU Leuven Center for Cancer Biology, VIB, Leuven, 3000, Belgium.
Blood flow produces shear stress exerted on the endothelial layer of the vessels. Spatial characterization of the endothelial proteome is required to uncover the mechanisms of endothelial activation by shear stress, as blood flow varies in the vasculature. An integrative ubiquitinome and proteome analysis of shear-stressed endothelial cells demonstrated that the non-degradative ubiquitination of several GTPases is regulated by mechano-signaling.
View Article and Find Full Text PDFRap1 coordinates cell-cell adhesion and cytoskeletal reorganization to drive collective cell migration in vivo.
Curr Biol
July 2023
Institute of Biomedical Engineering, University of Toronto, Toronto, ON M5S 3G9, Canada; Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research, University of Toronto, Toronto, ON M5G 1M1, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada; Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. Electronic address:
Collective cell movements contribute to tissue development and repair and spread metastatic disease. In epithelia, cohesive cell movements require reorganization of adherens junctions and the actomyosin cytoskeleton. However, the mechanisms that coordinate cell-cell adhesion and cytoskeletal remodeling during collective cell migration in vivo are unclear.
View Article and Find Full Text PDFs-Afadin binds to MAGUIN/Cnksr2 and regulates the localization of the AMPA receptor and glutamatergic synaptic response in hippocampal neurons.
J Biol Chem
April 2023
Department of Molecular and Cellular Neurobiology, Kitasato University Graduate School of Medical Sciences, Sagamihara, Kanagawa, Japan; Department of Biochemistry, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. Electronic address:
A hippocampal mossy fiber synapse implicated in learning and memory is a complex structure in which a presynaptic bouton attaches to the dendritic trunk by puncta adherentia junctions (PAJs) and wraps multiply branched spines. The postsynaptic densities (PSDs) are localized at the heads of each of these spines and faces to the presynaptic active zones. We previously showed that the scaffolding protein afadin regulates the formation of the PAJs, PSDs, and active zones in the mossy fiber synapse.
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