Many studies have compared active and passive touch to understand how motor action shapes touch perception. Current views emphasize the difficulties in making such a comparison and promote investigating how motor strategies enable the filtering out of sensory inputs to reshape touch perception. Cybulska-Klosowicz et al. (Cybulska-Klosowicz A, Tremblay F, Jiang W, Bourgeon S, Meftah E-M, Chapman CE. 123: 1072-1089, 2020) suggest that primary somatosensory (S1) cortical remodeling of digit representation occurs during active touch. Here, alternative interpretations are proposed, and the relevance of studying multidigit scanning is emphasized.
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http://dx.doi.org/10.1152/jn.00380.2020 | DOI Listing |
NPJ Digit Med
December 2024
IDG/McGovern Institute for Brain Research, Tsinghua University, 100084, Beijing, China.
Cognitive impairment, marked by neurodegenerative damage, leads to diminished cognitive function decline. Accurate cognitive assessment is crucial for early detection and progress evaluation, yet current methods in clinical practice lack objectivity, precision, and convenience. This study included 743 participants, including healthy individuals, mild cognitive impairment (MCI), and dementia patients, with collected resting-state EEG data and cognitive scale scores.
View Article and Find Full Text PDFJ Hand Surg Asian Pac Vol
December 2024
Department of Orthopaedics and Trauma, National Trauma Center, Kathmandu, Nepal.
Paediatric hand fractures account for approximately 25% of hand-related emergency department visits, making them the second most common childhood fractures after distal forearm fractures. These injuries are more prevalent in boys and peak ages between 9 and 14 years. Hand fractures in children are primarily caused by crushing injuries and, increasingly in older children, by sports-related activities.
View Article and Find Full Text PDFDigit Health
October 2024
College of Computer Science and Technology, Ocean University of China, Qingdao, China.
Objective: Long QT interval syndrome (LQTS) is a highly dangerous cardiac disease that can lead to sudden cardiac death; however, its underlying mechanism remains largely unknown. This study is conceived to investigate the impact of two general genotypes of LQTS type 2, and also the therapeutic effects of an emerging immunology-based treatment named KCNQ1 antibody.
Methods: A multiscale virtual heart is developed, which contains multiple biological levels ranging from ion channels to a three-dimensional cardiac structure with realistic geometry.
Basic Clin Pharmacol Toxicol
December 2024
Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai, China.
Cartilage
September 2024
Cell Sheet Tissue Engineering Center, Department of Molecular Pharmaceutics, Health Sciences, The University of Utah, Utah, USA.
Purpose: This study aimed to establish a combined histological assessment system of neo-cartilage outcomes and to evaluate variations in an established rat defect model treated with human juvenile cartilage-derived chondrocyte (JCC) sheets fabricated from various donors.
Methods: JCCs were isolated from the polydactylous digits of eight patients. Passage 2 (P2) JCC sheets from all donors were transplanted into nude rat chondral defects for 4 weeks (27 nude rats in total).
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