AI Article Synopsis
Article Abstract
Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these new prion isolates remain unknown. In this study to investigate zoonotic potential we inoculated brain tissue from CWD-infected Norwegian reindeer and moose into transgenic mice overexpressing human prion protein. After prolonged postinoculation survival periods no evidence for prion transmission was seen, suggesting that the zoonotic potential of these isolates is low.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9470110 | PMC |
| http://dx.doi.org/10.1093/infdis/jiab033 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Suspected Case of Persistent Thiamin Deficiency in a Hand-Reared Caribou Calf.
Zoo Biol
December 2024
Veterinary Services, Alaska Department of Fish and Game, Fairbanks, Alaska, USA.
Article Synopsis
- * A case study of a hand-reared calf with suspected thiamin deficiency showed that while thiamin injections initially helped, symptoms returned after stopping treatment.
- * Rumen transfaunation from a neighboring moose ultimately resolved the calf's thiamin deficiency, leading to no long-term health issues, and it’s recommended when injections alone aren't effective.
Climate change and deer in boreal and temperate regions: From physiology to population dynamics and species distributions.
Glob Chang Biol
September 2024
INRAE, EFNO, Nogent-sur-Vernisson, France.
Article Synopsis
- Climate change is impacting deer populations by pushing their physiological limits, where short-term individual adaptations may lead to long-term evolutionary changes.
- The review analyzed 218 studies from 2000-2022, focusing on how factors like temperature and rainfall affect various deer species across North America, Europe, and Asia, indicating that some may benefit from milder winters but suffer during hot summers.
- Important findings include that deer exhibit behavioral and physiological adaptations in response to climate variability, yet local factors like population density can influence their resilience, with significant knowledge gaps remaining in understanding impacts of extreme weather events.
Prion protein gene (PRNP) variation in German and Danish cervids.
Vet Res
August 2024
Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Greifswald, Isle of Riems, Germany.
The structure of cellular prion proteins encoded by the prion protein gene (PRNP) impacts susceptibility to transmissible spongiform encephalopathies, including chronic wasting disease (CWD) in deer. The recent emergence of CWD in Northern European reindeer (Rangifer tarandus), moose (Alces alces alces) and red deer (Cervus elaphus), in parallel with the outbreak in North America, gives reason to investigate PRNP variation in European deer, to implement risk assessments and adjust CWD management for deer populations under threat. We here report PRNP-sequence data from 911 samples of German red, roe (Capreolus capreolus), sika (Cervus nippon) and fallow deer (Dama dama) as well as additional data from 26 Danish red deer close to the German border and four zoo species not native to Germany.
View Article and Find Full Text PDFLack of prion transmission barrier in human PrP transgenic Drosophila.
J Biol Chem
September 2024
Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. Electronic address:
While animal prion diseases are a threat to human health, their zoonotic potential is generally inefficient because of interspecies prion transmission barriers. New animal models are required to provide an understanding of these prion transmission barriers and to assess the zoonotic potential of animal prion diseases. To address this goal, we generated Drosophila transgenic for human or nonhuman primate prion protein (PrP) and determined their susceptibility to known pathogenic prion diseases, namely varient Creutzfeldt-Jakob disease (vCJD) and classical bovine spongiform encephalopathy (BSE), and that with unknown pathogenic potential, namely chronic wasting disease (CWD).
View Article and Find Full Text PDFTransmission of Norwegian reindeer CWD to sheep by intracerebral inoculation results in an unusual phenotype and prion distribution.
Vet Res
July 2024
Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Sandnes, Norway.
Chronic wasting disease (CWD), a prion disease affecting cervids, has been known in North America (NA) since the 1960s and emerged in Norway in 2016. Surveillance and studies have revealed that there are different forms of CWD in Fennoscandia: contagious CWD in Norwegian reindeer and sporadic CWD in moose and red deer. Experimental studies have demonstrated that NA CWD prions can infect various species, but thus far, there have been no reports of natural transmission to non-cervid species.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!