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Chronic cough management: Practical guidelines and PICO-based evidence for screening and investigation.

Asian Pac J Allergy Immunol

December 2024

Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, T hailand.

Chronic cough is a common clinical condition requiring comprehensive assessment. This review employs a symptom-focused approach, prioritizing the presenting symptom of "chronic cough" to mirror real-world clinical practice. Ten key questions regarding the investigations in the uncertain areas were systematically addressed based on the PICO framework and applying the GRADE system for evidence synthesis to provide the strength of recommendation and quality of evidence for key questions.

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Background: Chondrosarcomas of the larynx, relatively rare tumors with low grade pathology in approximately 95% of cases, can most often be managed with conservation laryngeal procedures. Dedifferentiated chondrosarcomas are much more rare and aggressive requiring more aggressive surgical extirpation.

Methods: A patient underwent three debulking procedures for a laryngeal chondrosarcoma Grade I/II histologically over a 2.

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Background: There is limited large-scale data on the effect of obesity on thyroidectomy-specific outcomes. To fill this gap in the literature, this study evaluates the association between obesity and thyroidectomy-specific outcomes using a large real-world surgical outcomes dataset.

Materials And Methods: The 2016-2019 American College of Surgeons National Surgical Quality Improvement Program Targeted Thyroidectomy dataset (ACS NSQIP) was queried.

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Article Synopsis
  • - Papillary thyroid carcinoma typically presents as a painless, irregular mass in the thyroid region, often seen in middle-aged individuals; however, it may show varied symptoms like hoarseness and difficulty swallowing.
  • - A case study of a 63-year-old man showed an unusual presentation of this cancer, initially mistaken for lymphoma due to the absence of thyroid swelling and presence of multiple swollen lymph nodes in the neck.
  • - The case emphasizes the importance of fine-needle aspiration over excision biopsies in diagnosing neck swellings, as misdiagnosis or improper biopsy can lead to complications and worsen the prognosis for conditions like papillary thyroid carcinoma.
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A 52-year-old man presented with a one-year history of episodic unilateral facial numbness, jaw weakness, ptosis, and hoarseness. Brain imaging was unremarkable and an 11.5cm right lower thoracic mass was discovered on chest x-ray, which was further evaluated by CT and MRI radiology.

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