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Matrix-mediated activation of murine fibroblast-like synoviocytes.
Exp Cell Res
January 2025
Translational Matrix Biology, University of Cologne, Medical Faculty, Cologne, Germany. Electronic address:
Fibroblast-like synoviocytes (FLS) are key cells promoting cartilage damage and bone loss in rheumatoid arthritis (RA). They are activated to assume an invasive and migratory phenotype. While mechanisms of FLS activation are unknown, evidence suggests that pre-damaged extracellular matrix (ECM) of the cartilage can trigger FLS activation.
View Article and Find Full Text PDFValidation of lactate and glucose in cerebrospinal fluid (CSF) on a Radiometer blood gas analyzer ABL90 Flex plus.
Clin Biochem
January 2025
Pathology and Laboratory Medicine Program, Health Sciences Centre, St. John's, Newfoundland and Labrador, Canada; Memorial University of Newfoundland, Health Sciences Centre, St. John's, Newfoundland and Labrador, Canada. Electronic address:
Purpose: Rapid determination of cerebrospinal fluid. (CSF) glucose and lactate is required by emergency rooms and intensive care units. Long turnaround time (TAT) on test results negatively impacts timely diagnosis and treatment of neurological infections like meningitis.
View Article and Find Full Text PDFAssociation of phospholipid transfer protein (PLTP) and the effect of genetic variant rs5072 on hypertriglyceridemia and atherogenic dyslipidemia in children and adolescents from Southeastern Mexico.
Clin Biochem
January 2025
Health Department, El Colegio de la Frontera Sur, Carretera a Reforma Km. 15.5 s/n Ra, Guineo 2da. Sección, Villahermosa, Tabasco 86280, Mexico. Electronic address:
Introduction: Dyslipidemia is characterized by changes in lipid and lipoprotein levels in the blood where phospholipid transfer protein (PLTP) helps to regulate and modulate the size of high-density lipoproteins (HDL), working on the reverse transport of cholesterol. ApoA-1 is the primary protein component of HDL, and certain genetic variants like rs5072, have been associated with hypertriglyceridemia in children. This study aimed to explore the association between PLTP concentrations and the effect of the genetic variant APOA1 rs5072 on hypertriglyceridemia and atherogenic dyslipidemia (AD) in the pediatric population of Southeastern Mexico.
View Article and Find Full Text PDFPrevalence of antibiotic resistance genes in mining-impacted farmland environments.
Ecotoxicol Environ Saf
January 2025
SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Environmental Theoretical Chemistry, South China Normal University, Guangzhou 510006, China. Electronic address:
Mining activities produce large quantities of tailings and acid mine drainage, which contain varieties of heavy metals, thereby affecting the downstream farmland soils and crops. Heavy metals could induce antibiotic resistance through co-selection pressure. However, the profiles of antibiotic resistance genes (ARGs) in the mining-affected farmland soils and crops are still unclear.
View Article and Find Full Text PDFRole of early cognition/language in later language ability during childhood - A longitudinal comparison study.
Early Hum Dev
December 2024
Faculty of Medicine, Department of Speech-Language Pathology, University of Helsinki, Haartmaninkatu 3, 00014 Helsinki, Finland. Electronic address:
Background: Many factors may influence early language development, but the precise impact of cognitive development remains unclear.
Aims: This study aims to explore how cognitive development contributes to language ability and to compare the explanatory value of early cognitive and language ability at 2;0 (years;months) on the language ability at 3;6 and at 5;0.
Methods: Sixty-one typically developing children were followed up.
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